PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12941074-0	2003	Induction of cyclooxygenase-2 mRNA and protein expression in human gingival fibroblasts stimulated with nicotine.	Nicotine	104-112	prostaglandin-endoperoxide synthase 2	Homo sapiens	13-29	
12941074-4	2003	OBJECTIVES: The aim of the present study was to investigate the effects of nicotine on the expression of cyclooxygenase-2 (COX-2) mRNA gene and protein in cultured human gingival fibroblasts (HGFs).	Nicotine	75-83	prostaglandin-endoperoxide synthase 2	Homo sapiens	105-121	
12941074-4	2003	OBJECTIVES: The aim of the present study was to investigate the effects of nicotine on the expression of cyclooxygenase-2 (COX-2) mRNA gene and protein in cultured human gingival fibroblasts (HGFs).	Nicotine	75-83	prostaglandin-endoperoxide synthase 2	Homo sapiens	123-128	
12941074-5	2003	Furthermore, to elucidate whether induction of COX-2 may be associated with nicotine- induced cytotoxicity, NS-398 (a selective COX-2 inhibitor), was added to test its protective effect.	Nicotine	76-84	prostaglandin-endoperoxide synthase 2	Homo sapiens	47-52	
12941074-8	2003	RESULTS: The exposure of quiescent human HGFs to nicotine resulted in the induction of COX-2 mRNA expression.	Nicotine	49-57	prostaglandin-endoperoxide synthase 2	Homo sapiens	87-92	
12941074-9	2003	The levels of the COX-2 mRNAs increased about 1.5 and 2.5 fold after exposure to 2.5 and 15 mm nicotine for 2 h (P < 0.05), respectively.	Nicotine	95-103	prostaglandin-endoperoxide synthase 2	Homo sapiens	18-23	
12941074-10	2003	Moreover, the peak of COX-2 mRNA levels induced by nicotine was 10 mm at 2 h incubation period.	Nicotine	51-59	prostaglandin-endoperoxide synthase 2	Homo sapiens	22-27	
12941074-11	2003	Investigations of the time dependence of COX-2 mRNA expression in nicotine-treated HGFs revealed a rapid accumulation of the transcript, a signal first detectable at 30 min and diminished to control level after 8 h. In addition, 10 mm nicotine also induced COX-2 protein expression in HGFs.	Nicotine	66-74	prostaglandin-endoperoxide synthase 2	Homo sapiens	41-46	
12941074-11	2003	Investigations of the time dependence of COX-2 mRNA expression in nicotine-treated HGFs revealed a rapid accumulation of the transcript, a signal first detectable at 30 min and diminished to control level after 8 h. In addition, 10 mm nicotine also induced COX-2 protein expression in HGFs.	Nicotine	66-74	prostaglandin-endoperoxide synthase 2	Homo sapiens	257-262	
12941074-11	2003	Investigations of the time dependence of COX-2 mRNA expression in nicotine-treated HGFs revealed a rapid accumulation of the transcript, a signal first detectable at 30 min and diminished to control level after 8 h. In addition, 10 mm nicotine also induced COX-2 protein expression in HGFs.	Nicotine	235-243	prostaglandin-endoperoxide synthase 2	Homo sapiens	41-46	
12941074-11	2003	Investigations of the time dependence of COX-2 mRNA expression in nicotine-treated HGFs revealed a rapid accumulation of the transcript, a signal first detectable at 30 min and diminished to control level after 8 h. In addition, 10 mm nicotine also induced COX-2 protein expression in HGFs.	Nicotine	235-243	prostaglandin-endoperoxide synthase 2	Homo sapiens	257-262	
12941074-13	2003	CONCLUSIONS: Taken together, the activation of COX-2 expression by nicotine suggests a potential role for nicotine in the pathogenesis of smoking-associated periodontal disease.	Nicotine	67-75	prostaglandin-endoperoxide synthase 2	Homo sapiens	47-52	
12941074-13	2003	CONCLUSIONS: Taken together, the activation of COX-2 expression by nicotine suggests a potential role for nicotine in the pathogenesis of smoking-associated periodontal disease.	Nicotine	106-114	prostaglandin-endoperoxide synthase 2	Homo sapiens	47-52