PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12920172-3 2003 CYP2B11 and CYP3A12 effectively catalyzed the N1-demethylation and C3-hydroxylation of diazepam (and its derivatives), whereas CYP3A12 and CYP2D15 catalyzed exclusively the N- and O-demethylation, respectively, of dextromethorphan. Dextromethorphan 214-230 cytochrome P450 2D15 Canis lupus familiaris 139-146 12920172-5 2003 In contrast to CYP3A12, the CYP2D15-dependent O-demethylation of dextromethorphan was a low Km process (Km = 0.7 microM), similar to that in dog liver microsomes (Km = 2.3 microM). Dextromethorphan 65-81 cytochrome P450 2D15 Canis lupus familiaris 28-35