PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12907235-0	2003	Involvement of PKA and Sp1 in the induction of p27(Kip1) by tamoxifen.	Tamoxifen	60-69	cyclin dependent kinase inhibitor 1B	Homo sapiens	51-55	
12907235-1	2003	We have previously shown that tamoxifen (Tam) inhibits proliferation of estrogen receptor-negative human non-small cell lung cancer cells and this inhibition is associated with induction of p27(Kip1).	Tamoxifen	30-39	cyclin dependent kinase inhibitor 1B	Homo sapiens	194-198	
12907235-1	2003	We have previously shown that tamoxifen (Tam) inhibits proliferation of estrogen receptor-negative human non-small cell lung cancer cells and this inhibition is associated with induction of p27(Kip1).	Tamoxifen	41-44	cyclin dependent kinase inhibitor 1B	Homo sapiens	194-198	
12907235-2	2003	In this study, we investigated the mechanism by which Tam increases p27(Kip1) expression.	Tamoxifen	54-57	cyclin dependent kinase inhibitor 1B	Homo sapiens	72-76	
12907235-3	2003	Because intracellular p27(Kip1) protein level is mainly controlled via posttranslational regulation, we first tested whether Tam might affect protein stability of p27(Kip1).	Tamoxifen	125-128	cyclin dependent kinase inhibitor 1B	Homo sapiens	167-171	
12907235-5	2003	We next examined whether Tam enhanced p27(Kip1) expression through transcriptional activation.	Tamoxifen	25-28	cyclin dependent kinase inhibitor 1B	Homo sapiens	42-46	
12907235-6	2003	Our results demonstrated that Tam directly stimulated the p27(Kip1) promoter in lung cancer cells.	Tamoxifen	30-33	cyclin dependent kinase inhibitor 1B	Homo sapiens	62-66	
12907235-7	2003	Deletion and mutation analysis revealed that two Sp1 consensus sites located between -545 and -532bp from the transcription start site were crucial for the induction of p27(Kip1) by Tam.	Tamoxifen	182-185	cyclin dependent kinase inhibitor 1B	Homo sapiens	173-177	
12907235-10	2003	Our data also demonstrated that induction of p27(Kip1) by Tam was inhibited by protein kinase A inhibitor H89, but not by protein kinase C inhibitor calphostin C and mitogen-activated kinase kinase inhibitor PD98059.	Tamoxifen	58-61	cyclin dependent kinase inhibitor 1B	Homo sapiens	49-53	
12907235-11	2003	Taken together, our results suggest that Tam transcriptionally activates p27(Kip1) expression via the Sp1 consensus sites in the p27(Kip1) promoter and PKA is involved in this process.	Tamoxifen	41-44	cyclin dependent kinase inhibitor 1B	Homo sapiens	77-81	
12907235-11	2003	Taken together, our results suggest that Tam transcriptionally activates p27(Kip1) expression via the Sp1 consensus sites in the p27(Kip1) promoter and PKA is involved in this process.	Tamoxifen	41-44	cyclin dependent kinase inhibitor 1B	Homo sapiens	133-137