PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12904077-1 2003 It has been shown by extensive studies that alpha-MSH bioactivity is critically dependent on the core or central tetrapeptide sequence, His-Phe-Arg-Trp, however with poor selectivity for the human MC3R-MC5R. Histidine 136-139 proopiomelanocortin Homo sapiens 44-53