PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12898179-2 2004 In this study, we investigated the effect on cultured rheumatoid fibroblast-like synoviocytes (FLS) of the selective COX-2 inhibitor celecoxib on the expression of matrix metalloproteinases (MMPs), which play an important role in tissue degradation and angiogenesis in rheumatoid synovium. Celecoxib 133-142 matrix metallopeptidase 1 Homo sapiens 191-195 12898179-3 2004 Treatment with nontoxic doses of celecoxib resulted in dose-dependent inhibition of MMP-1, -2, and -3 secretion from FLS when measured by enzyme-linked immunosorbent assay. Celecoxib 33-42 matrix metallopeptidase 1 Homo sapiens 84-101