PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12800091-2 2003 However, its biological activity is severely compromised by the ubiquitous enzyme dipeptidylpeptidase IV (DPP IV), which removes the N-terminal Tyr(1)-Ala(2) dipeptide from GIP. Alanine 151-154 gastric inhibitory polypeptide Homo sapiens 173-176 12800091-3 2003 Therefore, 2 novel N-terminal Ala(2)-substituted analogs of GIP, with Ala substituted by 2-aminobutyric acid (Abu) or sarcosine (Sar), were synthesized and tested for metabolic stability and biological activity both in vitro and in vivo. Alanine 30-33 gastric inhibitory polypeptide Homo sapiens 60-63