PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12714600-0	2003	Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases.	Aspirin	0-7	insulin receptor substrate 1	Homo sapiens	43-71	
12714600-0	2003	Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases.	Aspirin	0-7	tumor necrosis factor	Homo sapiens	75-96	
12714600-0	2003	Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases.	Serine	17-23	insulin receptor substrate 1	Homo sapiens	43-71	
12714600-0	2003	Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases.	Serine	17-23	tumor necrosis factor	Homo sapiens	75-96	
12714600-3	2003	In this study, we analyzed the effects of aspirin (acetylsalicylic acid) on serine phosphorylation of insulin receptor substrate 1 (IRS-1) in cells treated with tumor necrosis factor (TNF)-alpha.	Aspirin	42-49	insulin receptor substrate 1	Homo sapiens	102-130	
12714600-3	2003	In this study, we analyzed the effects of aspirin (acetylsalicylic acid) on serine phosphorylation of insulin receptor substrate 1 (IRS-1) in cells treated with tumor necrosis factor (TNF)-alpha.	Aspirin	42-49	insulin receptor substrate 1	Homo sapiens	132-137	
12714600-3	2003	In this study, we analyzed the effects of aspirin (acetylsalicylic acid) on serine phosphorylation of insulin receptor substrate 1 (IRS-1) in cells treated with tumor necrosis factor (TNF)-alpha.	Aspirin	42-49	tumor necrosis factor	Homo sapiens	161-194	
12714600-3	2003	In this study, we analyzed the effects of aspirin (acetylsalicylic acid) on serine phosphorylation of insulin receptor substrate 1 (IRS-1) in cells treated with tumor necrosis factor (TNF)-alpha.	Aspirin	51-71	insulin receptor substrate 1	Homo sapiens	102-130	
12714600-3	2003	In this study, we analyzed the effects of aspirin (acetylsalicylic acid) on serine phosphorylation of insulin receptor substrate 1 (IRS-1) in cells treated with tumor necrosis factor (TNF)-alpha.	Aspirin	51-71	insulin receptor substrate 1	Homo sapiens	132-137	
12714600-3	2003	In this study, we analyzed the effects of aspirin (acetylsalicylic acid) on serine phosphorylation of insulin receptor substrate 1 (IRS-1) in cells treated with tumor necrosis factor (TNF)-alpha.	Aspirin	51-71	tumor necrosis factor	Homo sapiens	161-194	
12714600-3	2003	In this study, we analyzed the effects of aspirin (acetylsalicylic acid) on serine phosphorylation of insulin receptor substrate 1 (IRS-1) in cells treated with tumor necrosis factor (TNF)-alpha.	Serine	76-82	insulin receptor substrate 1	Homo sapiens	102-130	
12714600-3	2003	In this study, we analyzed the effects of aspirin (acetylsalicylic acid) on serine phosphorylation of insulin receptor substrate 1 (IRS-1) in cells treated with tumor necrosis factor (TNF)-alpha.	Serine	76-82	insulin receptor substrate 1	Homo sapiens	132-137	
12714600-3	2003	In this study, we analyzed the effects of aspirin (acetylsalicylic acid) on serine phosphorylation of insulin receptor substrate 1 (IRS-1) in cells treated with tumor necrosis factor (TNF)-alpha.	Serine	76-82	tumor necrosis factor	Homo sapiens	161-194	
12714600-7	2003	Taken together, these data suggest that serine phosphorylation of IRS-1 in response to TNF-alpha is mediated, in part, by JNK and IKK.	Serine	40-46	insulin receptor substrate 1	Homo sapiens	66-71	
12714600-7	2003	Taken together, these data suggest that serine phosphorylation of IRS-1 in response to TNF-alpha is mediated, in part, by JNK and IKK.	Serine	40-46	tumor necrosis factor	Homo sapiens	87-96	
12714600-7	2003	Taken together, these data suggest that serine phosphorylation of IRS-1 in response to TNF-alpha is mediated, in part, by JNK and IKK.	Serine	40-46	mitogen-activated protein kinase 8	Homo sapiens	122-125	
12714600-8	2003	Interestingly, aspirin treatment inhibited the phosphorylation of IRS-1 at Ser307 as well as the phosphorylation of JNK, c-Jun, and degradation of IkappaBalpha.	Aspirin	15-22	insulin receptor substrate 1	Homo sapiens	66-71	
12714600-8	2003	Interestingly, aspirin treatment inhibited the phosphorylation of IRS-1 at Ser307 as well as the phosphorylation of JNK, c-Jun, and degradation of IkappaBalpha.	Aspirin	15-22	mitogen-activated protein kinase 8	Homo sapiens	116-119	
12714600-8	2003	Interestingly, aspirin treatment inhibited the phosphorylation of IRS-1 at Ser307 as well as the phosphorylation of JNK, c-Jun, and degradation of IkappaBalpha.	Aspirin	15-22	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	121-126	
12714600-8	2003	Interestingly, aspirin treatment inhibited the phosphorylation of IRS-1 at Ser307 as well as the phosphorylation of JNK, c-Jun, and degradation of IkappaBalpha.	Aspirin	15-22	NFKB inhibitor alpha	Homo sapiens	147-159	
12714600-11	2003	Phosphorylation of Akt and the mammalian target of rapamycin (but not extracellular regulated kinase or PKCzeta) in response to TNF-alpha was inhibited by aspirin treatment.	Aspirin	155-162	AKT serine/threonine kinase 1	Homo sapiens	19-22	
12714600-11	2003	Phosphorylation of Akt and the mammalian target of rapamycin (but not extracellular regulated kinase or PKCzeta) in response to TNF-alpha was inhibited by aspirin treatment.	Aspirin	155-162	mechanistic target of rapamycin kinase	Homo sapiens	31-60	
12714600-11	2003	Phosphorylation of Akt and the mammalian target of rapamycin (but not extracellular regulated kinase or PKCzeta) in response to TNF-alpha was inhibited by aspirin treatment.	Aspirin	155-162	tumor necrosis factor	Homo sapiens	128-137	
12714600-12	2003	Finally, aspirin rescued insulin-induced glucose uptake in 3T3-L1 adipocytes pretreated with TNF-alpha.	Aspirin	9-16	insulin	Homo sapiens	25-32	
12714600-12	2003	Finally, aspirin rescued insulin-induced glucose uptake in 3T3-L1 adipocytes pretreated with TNF-alpha.	Aspirin	9-16	tumor necrosis factor	Homo sapiens	93-102	
12714600-12	2003	Finally, aspirin rescued insulin-induced glucose uptake in 3T3-L1 adipocytes pretreated with TNF-alpha.	Glucose	41-48	insulin	Homo sapiens	25-32	
12714600-12	2003	Finally, aspirin rescued insulin-induced glucose uptake in 3T3-L1 adipocytes pretreated with TNF-alpha.	Glucose	41-48	tumor necrosis factor	Homo sapiens	93-102	
12714600-13	2003	We conclude that aspirin may enhance insulin sensitivity by protecting IRS proteins from serine phosphorylation catalyzed by multiple kinases.	Aspirin	17-24	insulin	Homo sapiens	37-44	
12714600-13	2003	We conclude that aspirin may enhance insulin sensitivity by protecting IRS proteins from serine phosphorylation catalyzed by multiple kinases.	Aspirin	17-24	isoleucyl-tRNA synthetase 1	Homo sapiens	71-74	
12714600-13	2003	We conclude that aspirin may enhance insulin sensitivity by protecting IRS proteins from serine phosphorylation catalyzed by multiple kinases.	Serine	89-95	insulin	Homo sapiens	37-44	
12714600-13	2003	We conclude that aspirin may enhance insulin sensitivity by protecting IRS proteins from serine phosphorylation catalyzed by multiple kinases.	Serine	89-95	isoleucyl-tRNA synthetase 1	Homo sapiens	71-74