PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12640124-0	2003	Caveolin-induced activation of the phosphatidylinositol 3-kinase/Akt pathway increases arsenite cytotoxicity.	arsenite	87-95	AKT serine/threonine kinase 1	Homo sapiens	65-68	
12640124-6	2003	In contrast to its extensively documented antiapoptotic influence, the elevated activity of Akt appears to be important in sensitizing caveolin-expressing cells to arsenite-induced toxicity, as both pretreatment of cells with the PI3K inhibitor wortmannin and overexpression of a dominant-negative Akt mutant markedly improved the survival of arsenite-treated cells.	arsenite	164-172	AKT serine/threonine kinase 1	Homo sapiens	92-95	
12640124-6	2003	In contrast to its extensively documented antiapoptotic influence, the elevated activity of Akt appears to be important in sensitizing caveolin-expressing cells to arsenite-induced toxicity, as both pretreatment of cells with the PI3K inhibitor wortmannin and overexpression of a dominant-negative Akt mutant markedly improved the survival of arsenite-treated cells.	arsenite	343-351	AKT serine/threonine kinase 1	Homo sapiens	92-95	
12640124-8	2003	In summary, our results indicate that caveolin-induced upregulation of the PI3K/Akt signaling pathway, which appears to be a death signal in the presence of arsenite and H(2)O(2), sensitizes cells to environmental stress.	arsenite	157-165	AKT serine/threonine kinase 1	Homo sapiens	80-83