PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12618186-1 2003 Tyrosyl-DNA phosphodiesterase (Tdp1) is a member of the phospholipase D superfamily and acts as a DNA repair enzyme that removes stalled topoisomerase I- DNA complexes by hydrolyzing the bond between a tyrosine side chain and a DNA 3" phosphate. Tyrosine 202-210 tyrosyl-DNA phosphodiesterase 1 Homo sapiens 31-35 12618186-2 2003 Despite the complexity of the substrate of this phosphodiesterase, vanadate succeeded in linking human Tdp1, a tyrosine-containing peptide, and a single-stranded DNA oligonucleotide into a quaternary complex that mimics the transition state for the first step of the catalytic reaction. Tyrosine 111-119 tyrosyl-DNA phosphodiesterase 1 Homo sapiens 103-107