PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12578959-0 2003 An alpha-syntrophin-dependent pool of AQP4 in astroglial end-feet confers bidirectional water flow between blood and brain. Water 88-93 aquaporin 4 Mus musculus 38-42 12578959-6 2003 In the basal state, perivascular and subpial astroglial end-feet were swollen in brains of alpha-Syn(-/-) mice compared to WT mice, suggesting reduced clearance of water generated by brain metabolism. Water 164-169 synuclein, alpha Mus musculus 91-100 12578959-7 2003 When stressed by transient cerebral ischemia, brain edema was attenuated in alpha-Syn(-/-) mice, indicative of reduced water influx. Water 119-124 synuclein, alpha Mus musculus 76-85 12578959-10 2003 These studies identify a specific, syntrophin-dependent AQP4 pool that is expressed at distinct membrane domains and which mediates bidirectional transport of water across the brain-blood interface. Water 159-164 aquaporin 4 Mus musculus 56-60