PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12560222-0	2003	Inactivation of the human P2Y12 receptor by thiol reagents requires interaction with both extracellular cysteine residues, Cys17 and Cys270.	Sulfhydryl Compounds	44-49	purinergic receptor P2Y12	Homo sapiens	26-31	
12560222-0	2003	Inactivation of the human P2Y12 receptor by thiol reagents requires interaction with both extracellular cysteine residues, Cys17 and Cys270.	Cysteine	104-112	purinergic receptor P2Y12	Homo sapiens	26-31	
12560222-1	2003	Human platelets express 2 G protein-coupled nucleotide receptors: the platelet adenosine diphosphate (ADP) receptor coupled to stimulation of phospholipase C (P2Y(1)) via heterotrimeric guanosine 5-triphosphate (GTP)-binding protein G(q), and the platelet ADP receptor coupled to inhibition of adenylyl cyclase (P2Y(12)) via heterotrimeric GTP-binding protein G(i).	Guanosine Triphosphate	212-215	purinergic receptor P2Y1	Homo sapiens	159-165	
12560222-3	2003	The thiol agent p-chloromercuribenzene sulfonic acid (pCMBS) and the active metabolites from antiplatelet drugs, clopidogrel and CS-747, inactivate the P2Y(12) receptor and are predicted to interact with the extracellular cysteine residues on the P2Y(12) receptor.	Sulfhydryl Compounds	4-9	purinergic receptor P2Y12	Homo sapiens	152-159	
12560222-3	2003	The thiol agent p-chloromercuribenzene sulfonic acid (pCMBS) and the active metabolites from antiplatelet drugs, clopidogrel and CS-747, inactivate the P2Y(12) receptor and are predicted to interact with the extracellular cysteine residues on the P2Y(12) receptor.	Sulfhydryl Compounds	4-9	purinergic receptor P2Y12	Homo sapiens	247-254	
12560222-3	2003	The thiol agent p-chloromercuribenzene sulfonic acid (pCMBS) and the active metabolites from antiplatelet drugs, clopidogrel and CS-747, inactivate the P2Y(12) receptor and are predicted to interact with the extracellular cysteine residues on the P2Y(12) receptor.	Phosphorus	16-17	purinergic receptor P2Y12	Homo sapiens	152-159	
12560222-3	2003	The thiol agent p-chloromercuribenzene sulfonic acid (pCMBS) and the active metabolites from antiplatelet drugs, clopidogrel and CS-747, inactivate the P2Y(12) receptor and are predicted to interact with the extracellular cysteine residues on the P2Y(12) receptor.	Phosphorus	16-17	purinergic receptor P2Y12	Homo sapiens	247-254	
12560222-3	2003	The thiol agent p-chloromercuribenzene sulfonic acid (pCMBS) and the active metabolites from antiplatelet drugs, clopidogrel and CS-747, inactivate the P2Y(12) receptor and are predicted to interact with the extracellular cysteine residues on the P2Y(12) receptor.	chloromercuribenzene sulfonic acid	18-52	purinergic receptor P2Y12	Homo sapiens	152-159	
12560222-3	2003	The thiol agent p-chloromercuribenzene sulfonic acid (pCMBS) and the active metabolites from antiplatelet drugs, clopidogrel and CS-747, inactivate the P2Y(12) receptor and are predicted to interact with the extracellular cysteine residues on the P2Y(12) receptor.	chloromercuribenzene sulfonic acid	18-52	purinergic receptor P2Y12	Homo sapiens	247-254	
12560222-3	2003	The thiol agent p-chloromercuribenzene sulfonic acid (pCMBS) and the active metabolites from antiplatelet drugs, clopidogrel and CS-747, inactivate the P2Y(12) receptor and are predicted to interact with the extracellular cysteine residues on the P2Y(12) receptor.	4-Chloromercuribenzenesulfonate	54-59	purinergic receptor P2Y12	Homo sapiens	152-159	
12560222-3	2003	The thiol agent p-chloromercuribenzene sulfonic acid (pCMBS) and the active metabolites from antiplatelet drugs, clopidogrel and CS-747, inactivate the P2Y(12) receptor and are predicted to interact with the extracellular cysteine residues on the P2Y(12) receptor.	4-Chloromercuribenzenesulfonate	54-59	purinergic receptor P2Y12	Homo sapiens	247-254	
12560222-3	2003	The thiol agent p-chloromercuribenzene sulfonic acid (pCMBS) and the active metabolites from antiplatelet drugs, clopidogrel and CS-747, inactivate the P2Y(12) receptor and are predicted to interact with the extracellular cysteine residues on the P2Y(12) receptor.	Clopidogrel	113-124	purinergic receptor P2Y12	Homo sapiens	152-159	
12560222-3	2003	The thiol agent p-chloromercuribenzene sulfonic acid (pCMBS) and the active metabolites from antiplatelet drugs, clopidogrel and CS-747, inactivate the P2Y(12) receptor and are predicted to interact with the extracellular cysteine residues on the P2Y(12) receptor.	Clopidogrel	113-124	purinergic receptor P2Y12	Homo sapiens	247-254	
12560222-3	2003	The thiol agent p-chloromercuribenzene sulfonic acid (pCMBS) and the active metabolites from antiplatelet drugs, clopidogrel and CS-747, inactivate the P2Y(12) receptor and are predicted to interact with the extracellular cysteine residues on the P2Y(12) receptor.	Cesium	129-131	purinergic receptor P2Y12	Homo sapiens	152-159	
12560222-3	2003	The thiol agent p-chloromercuribenzene sulfonic acid (pCMBS) and the active metabolites from antiplatelet drugs, clopidogrel and CS-747, inactivate the P2Y(12) receptor and are predicted to interact with the extracellular cysteine residues on the P2Y(12) receptor.	Cesium	129-131	purinergic receptor P2Y12	Homo sapiens	247-254	
12560222-3	2003	The thiol agent p-chloromercuribenzene sulfonic acid (pCMBS) and the active metabolites from antiplatelet drugs, clopidogrel and CS-747, inactivate the P2Y(12) receptor and are predicted to interact with the extracellular cysteine residues on the P2Y(12) receptor.	Cysteine	222-230	purinergic receptor P2Y12	Homo sapiens	152-159	
12560222-4	2003	In this study we identified the reactive cysteine residues on the human P2Y(12) receptor by site-directed mutagenesis using pCMBS as the thiol reagent.	Cysteine	41-49	purinergic receptor P2Y12	Homo sapiens	72-79	
12560222-4	2003	In this study we identified the reactive cysteine residues on the human P2Y(12) receptor by site-directed mutagenesis using pCMBS as the thiol reagent.	4-Chloromercuribenzenesulfonate	124-129	purinergic receptor P2Y12	Homo sapiens	72-79	
12560222-4	2003	In this study we identified the reactive cysteine residues on the human P2Y(12) receptor by site-directed mutagenesis using pCMBS as the thiol reagent.	Sulfhydryl Compounds	137-142	purinergic receptor P2Y12	Homo sapiens	72-79	
12560222-5	2003	Cys97Ser and Cys175Ser mutants of the P2Y(12) receptor did not express when transfected into Chinese hamster ovary (CHO-K1) cells, indicating the essential nature of a disulfide bridge between these residues.	Disulfides	168-177	purinergic receptor P2Y12	Homo sapiens	38-45	
12560222-7	2003	Similarly, the median inhibitory concentration (IC(50)) values for BzATP (2",3"-O-(4- benzoylbenzoyl) adenosine 5"-triphosphate), an antagonist of the P2Y(12) receptor, also did not differ dramatically among these mutants and the wild-type P2Y(12) receptor.	3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate	67-72	purinergic receptor P2Y12	Homo sapiens	151-158	
12560222-10	2003	These results indicate that, unlike the P2Y(1) receptor, which has 2 essential disulfide bridges linking its extracellular domains, the P2Y(12) receptor has 2 free cysteines in its extracellular domains (Cys17 and Cys270), both of which are targets of thiol reagents.	Cysteine	164-173	purinergic receptor P2Y12	Homo sapiens	136-143	
12560222-10	2003	These results indicate that, unlike the P2Y(1) receptor, which has 2 essential disulfide bridges linking its extracellular domains, the P2Y(12) receptor has 2 free cysteines in its extracellular domains (Cys17 and Cys270), both of which are targets of thiol reagents.	Sulfhydryl Compounds	252-257	purinergic receptor P2Y12	Homo sapiens	136-143	
12560222-11	2003	We speculate that the active metabolites of clopidogrel and CS-747 form disulfide bridges with both Cys17 and Cys270 in the P2Y(12) receptor, and thereby inactivate the receptor.	Clopidogrel	44-55	purinergic receptor P2Y12	Homo sapiens	124-131	
12560222-11	2003	We speculate that the active metabolites of clopidogrel and CS-747 form disulfide bridges with both Cys17 and Cys270 in the P2Y(12) receptor, and thereby inactivate the receptor.	Cesium	60-62	purinergic receptor P2Y12	Homo sapiens	124-131	
12560222-11	2003	We speculate that the active metabolites of clopidogrel and CS-747 form disulfide bridges with both Cys17 and Cys270 in the P2Y(12) receptor, and thereby inactivate the receptor.	Disulfides	72-81	purinergic receptor P2Y12	Homo sapiens	124-131