PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12471138-0	2002	Hydrogen peroxide induces murine macrophage chemokine gene transcription via extracellular signal-regulated kinase- and cyclic adenosine 5"-monophosphate (cAMP)-dependent pathways: involvement of NF-kappa B, activator protein 1, and cAMP response element binding protein.	Hydrogen Peroxide	0-17	mitogen-activated protein kinase 1	Mus musculus	77-114	
12471138-0	2002	Hydrogen peroxide induces murine macrophage chemokine gene transcription via extracellular signal-regulated kinase- and cyclic adenosine 5"-monophosphate (cAMP)-dependent pathways: involvement of NF-kappa B, activator protein 1, and cAMP response element binding protein.	Hydrogen Peroxide	0-17	cathelicidin antimicrobial peptide	Mus musculus	120-153	
12471138-0	2002	Hydrogen peroxide induces murine macrophage chemokine gene transcription via extracellular signal-regulated kinase- and cyclic adenosine 5"-monophosphate (cAMP)-dependent pathways: involvement of NF-kappa B, activator protein 1, and cAMP response element binding protein.	Hydrogen Peroxide	0-17	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	196-227	
12471138-0	2002	Hydrogen peroxide induces murine macrophage chemokine gene transcription via extracellular signal-regulated kinase- and cyclic adenosine 5"-monophosphate (cAMP)-dependent pathways: involvement of NF-kappa B, activator protein 1, and cAMP response element binding protein.	Cyclic AMP	155-159	cathelicidin antimicrobial peptide	Mus musculus	120-153	
12471138-4	2002	Blockage of the ERK pathway with specific inhibitors against mitogen-activated protein kinase kinase 1/2 and ERK1/ERK2 completely abolished both the H(2)O(2)-mediated chemokine up-regulation and the activation of all NF studied.	Hydrogen Peroxide	149-157	mitogen-activated protein kinase 1	Mus musculus	16-19	
12471138-4	2002	Blockage of the ERK pathway with specific inhibitors against mitogen-activated protein kinase kinase 1/2 and ERK1/ERK2 completely abolished both the H(2)O(2)-mediated chemokine up-regulation and the activation of all NF studied.	Hydrogen Peroxide	149-157	mitogen-activated protein kinase kinase 1	Mus musculus	61-104	
12471138-4	2002	Blockage of the ERK pathway with specific inhibitors against mitogen-activated protein kinase kinase 1/2 and ERK1/ERK2 completely abolished both the H(2)O(2)-mediated chemokine up-regulation and the activation of all NF studied.	Hydrogen Peroxide	149-157	mitogen-activated protein kinase 3	Mus musculus	109-113	
12471138-4	2002	Blockage of the ERK pathway with specific inhibitors against mitogen-activated protein kinase kinase 1/2 and ERK1/ERK2 completely abolished both the H(2)O(2)-mediated chemokine up-regulation and the activation of all NF studied.	Hydrogen Peroxide	149-157	mitogen-activated protein kinase 1	Mus musculus	114-118	
12471138-5	2002	Similarly, selective inhibition of cAMP and NF-kappaB strongly down-regulated the induction of all chemokine transcripts as well as CREB and NF-kappaB activation, respectively.	Cyclic AMP	35-39	cAMP responsive element binding protein 1	Mus musculus	132-136	
12471138-6	2002	Of interest, we detected a significant decrease of NF-kappaB, AP-1, and CREB DNA binding activities by reciprocal competition for these binding sites when either specific cold oligonucleotides (NF-kappaB, AP-1, and CREB) or Abs against various transcription factor subunits (p50, p65, c-Fos, Jun B, c-Jun, and CREB-1) were added.	Oligonucleotides	176-192	cAMP responsive element binding protein 1	Mus musculus	72-76	
12471138-6	2002	Of interest, we detected a significant decrease of NF-kappaB, AP-1, and CREB DNA binding activities by reciprocal competition for these binding sites when either specific cold oligonucleotides (NF-kappaB, AP-1, and CREB) or Abs against various transcription factor subunits (p50, p65, c-Fos, Jun B, c-Jun, and CREB-1) were added.	Oligonucleotides	176-192	cAMP responsive element binding protein 1	Mus musculus	215-219	
12471138-6	2002	Of interest, we detected a significant decrease of NF-kappaB, AP-1, and CREB DNA binding activities by reciprocal competition for these binding sites when either specific cold oligonucleotides (NF-kappaB, AP-1, and CREB) or Abs against various transcription factor subunits (p50, p65, c-Fos, Jun B, c-Jun, and CREB-1) were added.	Oligonucleotides	176-192	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	275-278	
12471138-6	2002	Of interest, we detected a significant decrease of NF-kappaB, AP-1, and CREB DNA binding activities by reciprocal competition for these binding sites when either specific cold oligonucleotides (NF-kappaB, AP-1, and CREB) or Abs against various transcription factor subunits (p50, p65, c-Fos, Jun B, c-Jun, and CREB-1) were added.	Oligonucleotides	176-192	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	280-283	
12471138-6	2002	Of interest, we detected a significant decrease of NF-kappaB, AP-1, and CREB DNA binding activities by reciprocal competition for these binding sites when either specific cold oligonucleotides (NF-kappaB, AP-1, and CREB) or Abs against various transcription factor subunits (p50, p65, c-Fos, Jun B, c-Jun, and CREB-1) were added.	Oligonucleotides	176-192	FBJ osteosarcoma oncogene	Mus musculus	285-290	
12471138-6	2002	Of interest, we detected a significant decrease of NF-kappaB, AP-1, and CREB DNA binding activities by reciprocal competition for these binding sites when either specific cold oligonucleotides (NF-kappaB, AP-1, and CREB) or Abs against various transcription factor subunits (p50, p65, c-Fos, Jun B, c-Jun, and CREB-1) were added.	Oligonucleotides	176-192	jun B proto-oncogene	Mus musculus	292-297	
12471138-6	2002	Of interest, we detected a significant decrease of NF-kappaB, AP-1, and CREB DNA binding activities by reciprocal competition for these binding sites when either specific cold oligonucleotides (NF-kappaB, AP-1, and CREB) or Abs against various transcription factor subunits (p50, p65, c-Fos, Jun B, c-Jun, and CREB-1) were added.	Oligonucleotides	176-192	jun proto-oncogene	Mus musculus	299-304	
12471138-6	2002	Of interest, we detected a significant decrease of NF-kappaB, AP-1, and CREB DNA binding activities by reciprocal competition for these binding sites when either specific cold oligonucleotides (NF-kappaB, AP-1, and CREB) or Abs against various transcription factor subunits (p50, p65, c-Fos, Jun B, c-Jun, and CREB-1) were added.	Oligonucleotides	176-192	cAMP responsive element binding protein 1	Mus musculus	310-316	
12471138-8	2002	Finally, experiments performed with actinomycin D suggest that H(2)O(2)-mediated MIP-1beta mRNA up-regulation results from transcriptional control, whereas that of MIP-1alpha, MIP-2, and monocyte chemoattractant protein-1 is due to both gene transcription activation and mRNA posttranscriptional stabilization.	Dactinomycin	36-49	chemokine (C-C motif) ligand 4	Mus musculus	81-90	
12471138-8	2002	Finally, experiments performed with actinomycin D suggest that H(2)O(2)-mediated MIP-1beta mRNA up-regulation results from transcriptional control, whereas that of MIP-1alpha, MIP-2, and monocyte chemoattractant protein-1 is due to both gene transcription activation and mRNA posttranscriptional stabilization.	Hydrogen Peroxide	63-71	chemokine (C-C motif) ligand 4	Mus musculus	81-90