PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12426308-3 2003 IL-4 induces tyrosine phosphorylation of STAT6, which in turn leads to transcription of IL-4-specific genes. Tyrosine 13-21 interleukin 4 Mus musculus 0-4 12426308-3 2003 IL-4 induces tyrosine phosphorylation of STAT6, which in turn leads to transcription of IL-4-specific genes. Tyrosine 13-21 signal transducer and activator of transcription 6 Mus musculus 41-46 12426308-3 2003 IL-4 induces tyrosine phosphorylation of STAT6, which in turn leads to transcription of IL-4-specific genes. Tyrosine 13-21 interleukin 4 Mus musculus 88-92 12426308-4 2003 In addition, serine phosphorylation of STAT6 has recently been reported. Serine 13-19 signal transducer and activator of transcription 6 Mus musculus 39-44 12426308-5 2003 Here we study the functional role of STAT6 serine phosphorylation and the kinases and phosphatases involved. Serine 43-49 signal transducer and activator of transcription 6 Mus musculus 37-42 12426308-6 2003 We show that inhibition of protein phosphatase 2A (PP2A) induces serine phosphorylation of STAT6 and severely inhibits DNA binding of STAT6. Serine 65-71 protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform Mus musculus 51-55 12426308-6 2003 We show that inhibition of protein phosphatase 2A (PP2A) induces serine phosphorylation of STAT6 and severely inhibits DNA binding of STAT6. Serine 65-71 signal transducer and activator of transcription 6 Mus musculus 91-96 12426308-7 2003 In contrast, IL-4-induced tyrosine phosphorylation of Janus kinase-1 and STAT6 is not affected, suggesting that PP2A acts downstream of Janus kinases in IL-4 signaling. Tyrosine 26-34 interleukin 4 Mus musculus 13-17 12426308-7 2003 In contrast, IL-4-induced tyrosine phosphorylation of Janus kinase-1 and STAT6 is not affected, suggesting that PP2A acts downstream of Janus kinases in IL-4 signaling. Tyrosine 26-34 Janus kinase 1 Mus musculus 54-68