PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12204804-1 2002 High plasma homocysteine, a risk factor for atherosclerosis, is frequently caused by a common mutation in the gene for the enzyme, 5,10-methylenetetrahydrofolate reductase (MTHFR), C677T (alanine to valine substitution) or low intake of B vitamins that affect the remethylation or transsulfuration pathways in homocysteine metabolism. Alanine 188-195 methylenetetrahydrofolate reductase Homo sapiens 173-178