PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12163711-2 2002 In this study, we tested whether defective intracellular folate transport, as achieved by inactivation of the murine folate-binding protein 1 (Folbp1), affects global DNA methylation in the liver and brain from gestational day (GD) 15 embryos. Folic Acid 57-63 folate receptor 1 (adult) Mus musculus 117-141 12163711-2 2002 In this study, we tested whether defective intracellular folate transport, as achieved by inactivation of the murine folate-binding protein 1 (Folbp1), affects global DNA methylation in the liver and brain from gestational day (GD) 15 embryos. Folic Acid 57-63 folate receptor 1 (adult) Mus musculus 143-149 12163711-6 2002 FA-induced hypomethylation is most likely due to its ability to inhibit the enzyme glycine hydroxymethyltransferase, thereby inhibiting the homocysteine remethylation cycle necessary to regenerate S-adenosylmethionine, the methyl donor for DNA methyltransferases. Homocysteine 140-152 serine hydroxymethyltransferase 2 Homo sapiens 83-115 12163711-6 2002 FA-induced hypomethylation is most likely due to its ability to inhibit the enzyme glycine hydroxymethyltransferase, thereby inhibiting the homocysteine remethylation cycle necessary to regenerate S-adenosylmethionine, the methyl donor for DNA methyltransferases. S-Adenosylmethionine 197-217 serine hydroxymethyltransferase 2 Homo sapiens 83-115 12163711-7 2002 Our hypothesis was that due to defective folate transport in Folbp1(-/-) embryos and fetuses, DNA would be hypomethylated, thereby altering the temporal expression of critical genes necessary for normal embryonic development. Folic Acid 41-47 folate receptor 1 (adult) Mus musculus 61-67