PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11914744-11 2002 CONCLUSION/INTERPRETATION: IFN gamma and TNFalpha synergistically induced MHC class II expression on insulinoma cells through the induction of CIITA; nicotinamide reduced the expression of cytokine-induced MHC class II expression on insulinoma cells through its effect on CIITA expression; and the preventive effect of nicotimamide on Type I (insulin-dependent) diabetes mellitus is probably due to its effect of MHC class II expression rather than that on islet cell apoptosis. Niacinamide 150-162 interferon gamma Homo sapiens 27-36