PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11912557-0 2002 Retinoic acid 4-hydroxylase-mediated catabolism of all-trans retinoic acid and the cell proliferation in head and neck squamous cell carcinoma. Tretinoin 61-74 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 0-27 11912557-2 2002 The aim of this study was to confirm if retinoic acid 4-hydroxylase (CYP26) is a P450 induced by RA and to investigate the role of cellular RA binding proteins (CRABPs), using a slow catabolizer, AMC-HN-4, and a rapid catabolizer, AMC-HN-6. Tretinoin 97-99 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 40-67 11912557-2 2002 The aim of this study was to confirm if retinoic acid 4-hydroxylase (CYP26) is a P450 induced by RA and to investigate the role of cellular RA binding proteins (CRABPs), using a slow catabolizer, AMC-HN-4, and a rapid catabolizer, AMC-HN-6. Tretinoin 97-99 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 69-74 11912557-5 2002 The sensitivity to RA was variable by the amount of CYP26, and the rapid catabolism by CYP26 made AMC-HN-6 resistant to RA in vitro. Tretinoin 19-21 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 52-57 11912557-5 2002 The sensitivity to RA was variable by the amount of CYP26, and the rapid catabolism by CYP26 made AMC-HN-6 resistant to RA in vitro. Tretinoin 120-122 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 87-92 11912557-7 2002 Conclusively, the CYP26 activity might be one essential factor for the RA sensitivity, but in cells showing induction of CYP26, the RA sensitivity is inversely related to the rate of RA catabolism. Tretinoin 71-73 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 18-23 11912557-7 2002 Conclusively, the CYP26 activity might be one essential factor for the RA sensitivity, but in cells showing induction of CYP26, the RA sensitivity is inversely related to the rate of RA catabolism. Tretinoin 132-134 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 121-126 11912557-7 2002 Conclusively, the CYP26 activity might be one essential factor for the RA sensitivity, but in cells showing induction of CYP26, the RA sensitivity is inversely related to the rate of RA catabolism. Tretinoin 132-134 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 121-126