PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11893059-2 2001 The earliest known AChE inhibitors, namely, physostigmine and tacrine, performed poorly in clinical trials (e.g., poor oral activity, brain penetration, and hepatotoxic liability). Physostigmine 44-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23