PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11875115-1 2002 The appearance of a complex between tyrosine-phosphorylated insulin receptor substrate 1 (IRS-1) and PI3K in a high-speed pellet fraction (HSP) is thought to be a key event in insulin action. Tyrosine 36-44 insulin Homo sapiens 60-67 11875115-1 2002 The appearance of a complex between tyrosine-phosphorylated insulin receptor substrate 1 (IRS-1) and PI3K in a high-speed pellet fraction (HSP) is thought to be a key event in insulin action. Tyrosine 36-44 insulin receptor substrate 1 Homo sapiens 90-95 11875115-1 2002 The appearance of a complex between tyrosine-phosphorylated insulin receptor substrate 1 (IRS-1) and PI3K in a high-speed pellet fraction (HSP) is thought to be a key event in insulin action. Tyrosine 36-44 insulin Homo sapiens 176-183 11875115-4 2002 An in vitro pull-down assay using recombinant 14-3-3 revealed that insulin enhances the association of 14-3-3 with IRS-1 in cultured adipocytes and that this is completely inhibited by wortmannin. Wortmannin 185-195 insulin Homo sapiens 67-74 11875115-4 2002 An in vitro pull-down assay using recombinant 14-3-3 revealed that insulin enhances the association of 14-3-3 with IRS-1 in cultured adipocytes and that this is completely inhibited by wortmannin. Wortmannin 185-195 insulin receptor substrate 1 Homo sapiens 115-120 11875115-6 2002 Epidermal growth factor (EGF), 12-O-tetradecanoylphorbol-13-acetate, and okadaic acid, other agents that cause serine/threonine phosphorylation of IRS-1, also stimulated IRS binding to 14-3-3. Tetradecanoylphorbol Acetate 31-67 insulin receptor substrate 1 Homo sapiens 147-152 11875115-6 2002 Epidermal growth factor (EGF), 12-O-tetradecanoylphorbol-13-acetate, and okadaic acid, other agents that cause serine/threonine phosphorylation of IRS-1, also stimulated IRS binding to 14-3-3. Tetradecanoylphorbol Acetate 31-67 isoleucyl-tRNA synthetase 1 Homo sapiens 147-150 11875115-6 2002 Epidermal growth factor (EGF), 12-O-tetradecanoylphorbol-13-acetate, and okadaic acid, other agents that cause serine/threonine phosphorylation of IRS-1, also stimulated IRS binding to 14-3-3. Okadaic Acid 73-85 insulin receptor substrate 1 Homo sapiens 147-152 11875115-6 2002 Epidermal growth factor (EGF), 12-O-tetradecanoylphorbol-13-acetate, and okadaic acid, other agents that cause serine/threonine phosphorylation of IRS-1, also stimulated IRS binding to 14-3-3. Okadaic Acid 73-85 isoleucyl-tRNA synthetase 1 Homo sapiens 147-150 11875115-6 2002 Epidermal growth factor (EGF), 12-O-tetradecanoylphorbol-13-acetate, and okadaic acid, other agents that cause serine/threonine phosphorylation of IRS-1, also stimulated IRS binding to 14-3-3. Serine 111-117 epidermal growth factor Homo sapiens 0-23 11875115-6 2002 Epidermal growth factor (EGF), 12-O-tetradecanoylphorbol-13-acetate, and okadaic acid, other agents that cause serine/threonine phosphorylation of IRS-1, also stimulated IRS binding to 14-3-3. Serine 111-117 epidermal growth factor Homo sapiens 25-28 11875115-6 2002 Epidermal growth factor (EGF), 12-O-tetradecanoylphorbol-13-acetate, and okadaic acid, other agents that cause serine/threonine phosphorylation of IRS-1, also stimulated IRS binding to 14-3-3. Serine 111-117 insulin receptor substrate 1 Homo sapiens 147-152 11875115-6 2002 Epidermal growth factor (EGF), 12-O-tetradecanoylphorbol-13-acetate, and okadaic acid, other agents that cause serine/threonine phosphorylation of IRS-1, also stimulated IRS binding to 14-3-3. Serine 111-117 isoleucyl-tRNA synthetase 1 Homo sapiens 147-150 11875115-6 2002 Epidermal growth factor (EGF), 12-O-tetradecanoylphorbol-13-acetate, and okadaic acid, other agents that cause serine/threonine phosphorylation of IRS-1, also stimulated IRS binding to 14-3-3. Threonine 118-127 epidermal growth factor Homo sapiens 0-23 11875115-6 2002 Epidermal growth factor (EGF), 12-O-tetradecanoylphorbol-13-acetate, and okadaic acid, other agents that cause serine/threonine phosphorylation of IRS-1, also stimulated IRS binding to 14-3-3. Threonine 118-127 epidermal growth factor Homo sapiens 25-28 11875115-6 2002 Epidermal growth factor (EGF), 12-O-tetradecanoylphorbol-13-acetate, and okadaic acid, other agents that cause serine/threonine phosphorylation of IRS-1, also stimulated IRS binding to 14-3-3. Threonine 118-127 insulin receptor substrate 1 Homo sapiens 147-152 11875115-6 2002 Epidermal growth factor (EGF), 12-O-tetradecanoylphorbol-13-acetate, and okadaic acid, other agents that cause serine/threonine phosphorylation of IRS-1, also stimulated IRS binding to 14-3-3. Threonine 118-127 isoleucyl-tRNA synthetase 1 Homo sapiens 147-150 11875115-11 2002 These findings strongly suggest that 14-3-3 participates in the intracellular trafficking of IRS-1 by promoting the displacement of serine-phosphorylated IRS-1 from particular structures. Serine 132-138 insulin receptor substrate 1 Homo sapiens 93-98 11875115-11 2002 These findings strongly suggest that 14-3-3 participates in the intracellular trafficking of IRS-1 by promoting the displacement of serine-phosphorylated IRS-1 from particular structures. Serine 132-138 insulin receptor substrate 1 Homo sapiens 154-159