PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11864911-1	2002	We have investigated the mechanism of S-phase arrest elicited by the carcinogen benzo(a)pyrene dihydrodiol epoxide (BPDE) in p53-deficient cells.	pyrene dihydrodiol epoxide	88-114	tumor protein p53	Homo sapiens	125-128	
11864911-1	2002	We have investigated the mechanism of S-phase arrest elicited by the carcinogen benzo(a)pyrene dihydrodiol epoxide (BPDE) in p53-deficient cells.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	116-120	tumor protein p53	Homo sapiens	125-128	
11864911-4	2002	The checkpoint kinase Chk1 (but not Chk2) was phosphorylated after treatment with low doses of BPDE.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	95-99	checkpoint kinase 1	Homo sapiens	22-26	
11864911-5	2002	High concentrations of BPDE elicited phosphorylation of both Chk1 and Chk2.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	23-27	checkpoint kinase 1	Homo sapiens	61-65	
11864911-5	2002	High concentrations of BPDE elicited phosphorylation of both Chk1 and Chk2.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	23-27	checkpoint kinase 2	Homo sapiens	70-74	
11864911-6	2002	Adenovirus-mediated expression of "dominant-negative" Chk1 (but not dominant-negative Chk2) and the Chk1 inhibitor UCN-01 abrogated the S-phase delay elicited by low doses of BPDE.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	175-179	checkpoint kinase 1	Homo sapiens	54-58	
11864911-6	2002	Adenovirus-mediated expression of "dominant-negative" Chk1 (but not dominant-negative Chk2) and the Chk1 inhibitor UCN-01 abrogated the S-phase delay elicited by low doses of BPDE.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	175-179	checkpoint kinase 1	Homo sapiens	100-104	
11864911-6	2002	Adenovirus-mediated expression of "dominant-negative" Chk1 (but not dominant-negative Chk2) and the Chk1 inhibitor UCN-01 abrogated the S-phase delay elicited by low doses of BPDE.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	175-179	urocortin	Homo sapiens	115-118	
11864911-7	2002	Consistent with a role for the caffeine-sensitive ATM or ATR protein kinase in low-dose BPDE-induced S-phase arrest, both Chk1 phosphorylation and S-phase arrest were abrogated by caffeine.	Caffeine	31-39	ATM serine/threonine kinase	Homo sapiens	50-53	
11864911-7	2002	Consistent with a role for the caffeine-sensitive ATM or ATR protein kinase in low-dose BPDE-induced S-phase arrest, both Chk1 phosphorylation and S-phase arrest were abrogated by caffeine.	Caffeine	31-39	checkpoint kinase 1	Homo sapiens	122-126	
11864911-7	2002	Consistent with a role for the caffeine-sensitive ATM or ATR protein kinase in low-dose BPDE-induced S-phase arrest, both Chk1 phosphorylation and S-phase arrest were abrogated by caffeine.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	88-92	ATM serine/threonine kinase	Homo sapiens	50-53	
11864911-7	2002	Consistent with a role for the caffeine-sensitive ATM or ATR protein kinase in low-dose BPDE-induced S-phase arrest, both Chk1 phosphorylation and S-phase arrest were abrogated by caffeine.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	88-92	checkpoint kinase 1	Homo sapiens	122-126	
11864911-7	2002	Consistent with a role for the caffeine-sensitive ATM or ATR protein kinase in low-dose BPDE-induced S-phase arrest, both Chk1 phosphorylation and S-phase arrest were abrogated by caffeine.	Caffeine	180-188	ATM serine/threonine kinase	Homo sapiens	50-53	
11864911-7	2002	Consistent with a role for the caffeine-sensitive ATM or ATR protein kinase in low-dose BPDE-induced S-phase arrest, both Chk1 phosphorylation and S-phase arrest were abrogated by caffeine.	Caffeine	180-188	checkpoint kinase 1	Homo sapiens	122-126	
11864911-8	2002	However, low doses of BPDE elicited Chk1 phosphorylation and S-phase arrest in AT cells (from ataxia telangiectasia patients), demonstrating that ATM is dispensable for S-phase checkpoint responses to this genotoxin.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	22-26	checkpoint kinase 1	Homo sapiens	36-40	
11864911-8	2002	However, low doses of BPDE elicited Chk1 phosphorylation and S-phase arrest in AT cells (from ataxia telangiectasia patients), demonstrating that ATM is dispensable for S-phase checkpoint responses to this genotoxin.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	22-26	ATM serine/threonine kinase	Homo sapiens	146-149	
11864911-9	2002	BPDE-induced Chk1 phosphorylation and S-phase arrest were abrogated by caffeine treatment in AT cells, suggesting that a caffeine-sensitive kinase other than ATM is an important mediator of responses to BPDE-adducted DNA.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	0-4	checkpoint kinase 1	Homo sapiens	13-17	
11864911-9	2002	BPDE-induced Chk1 phosphorylation and S-phase arrest were abrogated by caffeine treatment in AT cells, suggesting that a caffeine-sensitive kinase other than ATM is an important mediator of responses to BPDE-adducted DNA.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	203-207	checkpoint kinase 1	Homo sapiens	13-17	
11864911-10	2002	Overall, our data demonstrate the existence of a caffeine-sensitive, Chk1-mediated, S-phase checkpoint that is operational in response to BPDE.	Caffeine	49-57	checkpoint kinase 1	Homo sapiens	69-73	
11864911-10	2002	Overall, our data demonstrate the existence of a caffeine-sensitive, Chk1-mediated, S-phase checkpoint that is operational in response to BPDE.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	138-142	checkpoint kinase 1	Homo sapiens	69-73