PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11756188-3 2002 CDDO-Me decreased the viability of leukemic cell lines, including multidrug resistant (MDR)-1-overexpressing, p53(null) HL-60-Dox and of primary AML cells, and it was 3- to 5-fold more active than CDDO. bardoxolone methyl 0-7 tumor protein p53 Homo sapiens 110-113 11756188-10 2002 In conclusion, CDDO-Me is an MDR-1- and a p53-independent compound that exerts strong antiproliferative, apoptotic, and differentiating effects in myeloid leukemic cell lines and in primary AML samples when given in submicromolar concentrations. bardoxolone methyl 15-22 tumor protein p53 Homo sapiens 42-45