PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11733347-0	2001	Aluminum chloride pretreatment of elastin inhibits elastolysis by matrix metalloproteinases and leads to inhibition of elastin-oriented calcification.	Aluminum Chloride	0-17	elastin	Rattus norvegicus	34-41	
11733347-0	2001	Aluminum chloride pretreatment of elastin inhibits elastolysis by matrix metalloproteinases and leads to inhibition of elastin-oriented calcification.	Aluminum Chloride	0-17	elastin	Rattus norvegicus	119-126	
11733347-2	2001	We have previously shown that purified elastin when subdermally implanted in rats undergoes severe calcification and aluminum chloride (AlCl(3)) pretreatment of elastin inhibits calcification.	Aluminum Chloride	117-134	elastin	Rattus norvegicus	39-46	
11733347-2	2001	We have previously shown that purified elastin when subdermally implanted in rats undergoes severe calcification and aluminum chloride (AlCl(3)) pretreatment of elastin inhibits calcification.	Aluminum Chloride	117-134	elastin	Rattus norvegicus	161-168	
11733347-2	2001	We have previously shown that purified elastin when subdermally implanted in rats undergoes severe calcification and aluminum chloride (AlCl(3)) pretreatment of elastin inhibits calcification.	Aluminum Chloride	136-143	elastin	Rattus norvegicus	161-168	
11733347-3	2001	In the present study we investigated whether matrix metalloproteinase (MMP) binding to elastin and elastin degradation is prevented by AlCl(3) pretreatment.	Aluminum Chloride	135-142	elastin	Rattus norvegicus	87-94	
11733347-3	2001	In the present study we investigated whether matrix metalloproteinase (MMP) binding to elastin and elastin degradation is prevented by AlCl(3) pretreatment.	Aluminum Chloride	135-142	elastin	Rattus norvegicus	99-106	
11733347-4	2001	Subdermal implantation of AlCl(3)-pretreated elastin showed significantly lower MMP-9 and MMP-2 activity surrounding the implant as compared to the control implants.	Aluminum Chloride	26-33	elastin	Rattus norvegicus	45-52	
11733347-4	2001	Subdermal implantation of AlCl(3)-pretreated elastin showed significantly lower MMP-9 and MMP-2 activity surrounding the implant as compared to the control implants.	Aluminum Chloride	26-33	matrix metallopeptidase 9	Rattus norvegicus	80-85	
11733347-4	2001	Subdermal implantation of AlCl(3)-pretreated elastin showed significantly lower MMP-9 and MMP-2 activity surrounding the implant as compared to the control implants.	Aluminum Chloride	26-33	matrix metallopeptidase 2	Rattus norvegicus	90-95	
11733347-5	2001	AlCl(3) pretreatment also significantly inhibited elastin implant calcification at the seven-day implant period (AlCl(3)-pretreated 4.07 +/- 1.27, control 23.82 +/- 2.24 microg/mg; p<0.0001).	Aluminum Chloride	0-7	elastin	Rattus norvegicus	50-57	
11733347-5	2001	AlCl(3) pretreatment also significantly inhibited elastin implant calcification at the seven-day implant period (AlCl(3)-pretreated 4.07 +/- 1.27, control 23.82 +/- 2.24 microg/mg; p<0.0001).	Aluminum Chloride	113-120	elastin	Rattus norvegicus	50-57	
11733347-6	2001	Moreover, elastin gel zymography studies showed that gel pretreatment with AlCl(3) inhibited elastolysis by MMP-9.	Aluminum Chloride	75-82	elastin	Rattus norvegicus	10-17	
11733347-6	2001	Moreover, elastin gel zymography studies showed that gel pretreatment with AlCl(3) inhibited elastolysis by MMP-9.	Aluminum Chloride	75-82	matrix metallopeptidase 9	Rattus norvegicus	108-113	
11733347-7	2001	We also demonstrate significant suppression of MMP-2 activity in aortic wall segments of AlCl(3)-pretreated porcine bioprosthetic heart valve implants as compared to control valve implants in sheep mitral valve replacement studies.	Aluminum Chloride	89-96	72 kDa type IV collagenase	Ovis aries	47-52	
11733347-8	2001	AlCl(3) pretreatment also significantly inhibited calcification of elastin in this model.	Aluminum Chloride	0-7	elastin	Rattus norvegicus	67-74	
11733347-9	2001	Thus, we conclude that aluminum ion binding to elastin prevents MMP-mediated elastolysis and thus prevents elastin calcification.	Aluminum	23-31	elastin	Rattus norvegicus	47-54	
11733347-9	2001	Thus, we conclude that aluminum ion binding to elastin prevents MMP-mediated elastolysis and thus prevents elastin calcification.	Aluminum	23-31	elastin	Rattus norvegicus	107-114