PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11574492-1 2001 BACKGROUND: The present study was conducted to investigate the effect of androstenedione, insulin and LH on human granulosa cell oestrogen and progesterone production. Progesterone 143-155 insulin Homo sapiens 90-97 11574492-5 2001 RESULTS: Insulin increased the basal secretion of steroid hormones, and furthermore augmented LH-stimulated oestrogen and progesterone accumulation in granulosa cell cultures. Progesterone 122-134 insulin Homo sapiens 9-16 11574492-7 2001 CONCLUSION: These results suggest that high androstenedione concentrations may act directly to impair insulin augmentation of LH-stimulated oestradiol and progesterone production in cultured human granulosa luteal cells. Progesterone 155-167 insulin Homo sapiens 102-109