PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11448460-1	2001	We studied the activities of 3",5"-adenosine-cyclic monophosphate (cAMP)- synthesizing adenylate cyclase (AC) and cAMP-hydrolyzing cyclic nucleotide phosphodiesterase (PDE) in phytohemagglutinin (PHA)- or anti-CD3 plus anti-CD28-stimulated human T cells, and examined their roles in interleukin-13 (IL-13) production.	3",5"-adenosine-cyclic monophosphate	29-65	CD28 molecule	Homo sapiens	224-228	
11448460-1	2001	We studied the activities of 3",5"-adenosine-cyclic monophosphate (cAMP)- synthesizing adenylate cyclase (AC) and cAMP-hydrolyzing cyclic nucleotide phosphodiesterase (PDE) in phytohemagglutinin (PHA)- or anti-CD3 plus anti-CD28-stimulated human T cells, and examined their roles in interleukin-13 (IL-13) production.	3",5"-adenosine-cyclic monophosphate	29-65	interleukin 13	Homo sapiens	283-297	
11448460-1	2001	We studied the activities of 3",5"-adenosine-cyclic monophosphate (cAMP)- synthesizing adenylate cyclase (AC) and cAMP-hydrolyzing cyclic nucleotide phosphodiesterase (PDE) in phytohemagglutinin (PHA)- or anti-CD3 plus anti-CD28-stimulated human T cells, and examined their roles in interleukin-13 (IL-13) production.	3",5"-adenosine-cyclic monophosphate	29-65	interleukin 13	Homo sapiens	299-304	
11448460-2	2001	The AC inhibitor MDL 12,330A [cis-N-(2-phenylcyclopentyl)azacyclotridec-1-en-2-amine hydrochloride] completely blocked PHA- or anti-CD3/CD28-induced IL-13 production.	mdl 12	17-23	CD28 molecule	Homo sapiens	136-140	
11448460-2	2001	The AC inhibitor MDL 12,330A [cis-N-(2-phenylcyclopentyl)azacyclotridec-1-en-2-amine hydrochloride] completely blocked PHA- or anti-CD3/CD28-induced IL-13 production.	mdl 12	17-23	interleukin 13	Homo sapiens	149-154	
11448460-2	2001	The AC inhibitor MDL 12,330A [cis-N-(2-phenylcyclopentyl)azacyclotridec-1-en-2-amine hydrochloride] completely blocked PHA- or anti-CD3/CD28-induced IL-13 production.	330a	24-28	CD28 molecule	Homo sapiens	136-140	
11448460-2	2001	The AC inhibitor MDL 12,330A [cis-N-(2-phenylcyclopentyl)azacyclotridec-1-en-2-amine hydrochloride] completely blocked PHA- or anti-CD3/CD28-induced IL-13 production.	330a	24-28	interleukin 13	Homo sapiens	149-154	
11448460-2	2001	The AC inhibitor MDL 12,330A [cis-N-(2-phenylcyclopentyl)azacyclotridec-1-en-2-amine hydrochloride] completely blocked PHA- or anti-CD3/CD28-induced IL-13 production.	cis-n-(2-phenylcyclopentyl)azacyclotridec-1-en-2-amine hydrochloride	30-98	CD28 molecule	Homo sapiens	136-140	
11448460-2	2001	The AC inhibitor MDL 12,330A [cis-N-(2-phenylcyclopentyl)azacyclotridec-1-en-2-amine hydrochloride] completely blocked PHA- or anti-CD3/CD28-induced IL-13 production.	cis-n-(2-phenylcyclopentyl)azacyclotridec-1-en-2-amine hydrochloride	30-98	interleukin 13	Homo sapiens	149-154	
11448460-3	2001	The PDE 1 inhibitor 8-methoxymethyl-3-isobutyl-1-methylxanthine or the PDE4 inhibitor rolipram partially inhibited IL-13 production, and the addition of both resulted in 100 or 85% inhibition in PHA- or anti-CD3/CD28-stimulated T cells, respectively.	8-methoxymethyl-3-isobutyl-1-methylxanthine	20-63	interleukin 13	Homo sapiens	115-120	
11448460-3	2001	The PDE 1 inhibitor 8-methoxymethyl-3-isobutyl-1-methylxanthine or the PDE4 inhibitor rolipram partially inhibited IL-13 production, and the addition of both resulted in 100 or 85% inhibition in PHA- or anti-CD3/CD28-stimulated T cells, respectively.	8-methoxymethyl-3-isobutyl-1-methylxanthine	20-63	CD28 molecule	Homo sapiens	212-216	
11448460-3	2001	The PDE 1 inhibitor 8-methoxymethyl-3-isobutyl-1-methylxanthine or the PDE4 inhibitor rolipram partially inhibited IL-13 production, and the addition of both resulted in 100 or 85% inhibition in PHA- or anti-CD3/CD28-stimulated T cells, respectively.	Rolipram	86-94	phosphodiesterase 4A	Homo sapiens	71-75	
11448460-3	2001	The PDE 1 inhibitor 8-methoxymethyl-3-isobutyl-1-methylxanthine or the PDE4 inhibitor rolipram partially inhibited IL-13 production, and the addition of both resulted in 100 or 85% inhibition in PHA- or anti-CD3/CD28-stimulated T cells, respectively.	Rolipram	86-94	interleukin 13	Homo sapiens	115-120	
11448460-6	2001	Although PDE1-, 2-, 3-, and 4-independent PDE activity was low (< or = 15% of total), it began to increase 3 hr after anti-CD3/CD28; the increase was blocked by PDE7 antisense oligonucleotide, and such an increase was not induced by PHA.	Oligonucleotides	179-194	phosphodiesterase 7A	Homo sapiens	164-168	
11448460-11	2001	These results suggest that PHA or anti-CD3/CD28 initially (< or = 5 min) increases cAMP in T cells via AC, then reverses the increase via PDE4 (< or = 2 hr), and in the later phase (> 2 hr) further decreases cAMP via PDE1.	Cyclic AMP	86-90	CD28 molecule	Homo sapiens	43-47	
11448460-11	2001	These results suggest that PHA or anti-CD3/CD28 initially (< or = 5 min) increases cAMP in T cells via AC, then reverses the increase via PDE4 (< or = 2 hr), and in the later phase (> 2 hr) further decreases cAMP via PDE1.	Cyclic AMP	217-221	CD28 molecule	Homo sapiens	43-47	
11448460-12	2001	Both the time-dependent increase and decrease of cAMP may be required for IL-13 production.	Cyclic AMP	49-53	interleukin 13	Homo sapiens	74-79