PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11391481-10 2001 The increased activity of CBS in children with DS significantly alters homocysteine metabolism such that the folate-dependent resynthesis of methionine is compromised. Folic Acid 109-115 cystathionine beta-synthase Homo sapiens 26-29