PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11233292-1	2001	To investigate the involvement of catecholamines and/or the cyclic AMP (cAMP) systems in the development of drug dependence, we examined whether morphine dependence was developed in tyrosine hydroxylase (TH) heterozygous (TH+/-) and cAMP response element binding protein (CREB) binding protein (CBP) heterozygous (CBP+/-) mice.	Morphine	145-153	tyrosine hydroxylase	Mus musculus	204-206	
11233292-5	2001	However, increased numbers of jumping and forepaw tremor in the TH+/- and CBP+/- mice and increased level of cAMP in the thalamus/hypothalamus of TH+/- mice were not observed.	Cyclic AMP	109-113	tyrosine hydroxylase	Mus musculus	146-148	
11233292-6	2001	These results suggest that catecholamines and CBP are involved in the development of morphine dependence, and that some changes in the catecholaminergic and/or cAMP system induced by repeated morphine treatment play an important role in the addiction of morphine.	Morphine	85-93	CREB binding protein	Mus musculus	46-49	
11233292-6	2001	These results suggest that catecholamines and CBP are involved in the development of morphine dependence, and that some changes in the catecholaminergic and/or cAMP system induced by repeated morphine treatment play an important role in the addiction of morphine.	Morphine	192-200	CREB binding protein	Mus musculus	46-49	
11233292-6	2001	These results suggest that catecholamines and CBP are involved in the development of morphine dependence, and that some changes in the catecholaminergic and/or cAMP system induced by repeated morphine treatment play an important role in the addiction of morphine.	Morphine	192-200	CREB binding protein	Mus musculus	46-49