PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11203012-3 2000 The mechanism of antitumour action with the new sulfonamides reported here is unknown, but it might involve either inhibition of several CA isozymes (such as CA IX, CA XII, CA XIV) present predominantly in tumour cell membranes, acidification of the intracellular environment as a consequence of CA inhibition, uncoupling of mitochondria and/or strong CA V inhibition, or a combination of several such mechanisms. Sulfonamides 48-60 carbonic anhydrase 5A Homo sapiens 352-356