PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11200073-0 2001 Subthreshold concentrations of anti-proteinase 3 antibodies (c-ANCA) specifically prime human neutrophils for fMLP-induced leukotriene synthesis and chemotaxis. Leukotrienes 123-134 formyl peptide receptor 1 Homo sapiens 110-114 11200073-4 2001 Preincubation with anti-PR3 resulted in a massive amplification of N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced leukotriene (LT) generation, with a marked increase in the liberation of LTB4, LTA4, and 5-hydroxyeicosatetraenoic acid (5-HETE). Leukotrienes 122-133 formyl peptide receptor 1 Homo sapiens 108-112 11200073-10 2001 We conclude that subthreshold concentrations of anti-PR3 antibodies selectively modify neutrophil responses to fMLP, with enhancement of leukotriene generation and chemotaxis, but suppression of respiratory burst and degranulation. Leukotrienes 137-148 formyl peptide receptor 1 Homo sapiens 111-115