PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11160867-5 2001 Here, the role of NF-kappaB, a lymphocyte survival factor, in PAH-induced preB cell apoptosis was assessed. Polycyclic Aromatic Hydrocarbons 62-65 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 18-27 11160867-7 2001 NF-kappaB down-regulation with previously described inhibitors induced BU-11 cell apoptosis, demonstrating that the default apoptosis pathway blocked by NF-kappaB is functional at this early stage in B cell development. bu-11 71-76 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 0-9 11160867-7 2001 NF-kappaB down-regulation with previously described inhibitors induced BU-11 cell apoptosis, demonstrating that the default apoptosis pathway blocked by NF-kappaB is functional at this early stage in B cell development. bu-11 71-76 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 153-162 11160867-8 2001 Similarly, exposure of BU-11/BMS2 cocultures to 7,12-dimethylbenz[a]anthracene (DMBA), a prototypic PAH, down-regulated nuclear Rel A and c-Rel before overt apoptosis. bu-11 23-28 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 128-133 11160867-8 2001 Similarly, exposure of BU-11/BMS2 cocultures to 7,12-dimethylbenz[a]anthracene (DMBA), a prototypic PAH, down-regulated nuclear Rel A and c-Rel before overt apoptosis. bu-11 23-28 reticuloendotheliosis oncogene Mus musculus 138-143 11160867-8 2001 Similarly, exposure of BU-11/BMS2 cocultures to 7,12-dimethylbenz[a]anthracene (DMBA), a prototypic PAH, down-regulated nuclear Rel A and c-Rel before overt apoptosis. bms2 29-33 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 128-133 11160867-8 2001 Similarly, exposure of BU-11/BMS2 cocultures to 7,12-dimethylbenz[a]anthracene (DMBA), a prototypic PAH, down-regulated nuclear Rel A and c-Rel before overt apoptosis. bms2 29-33 reticuloendotheliosis oncogene Mus musculus 138-143 11160867-8 2001 Similarly, exposure of BU-11/BMS2 cocultures to 7,12-dimethylbenz[a]anthracene (DMBA), a prototypic PAH, down-regulated nuclear Rel A and c-Rel before overt apoptosis. 9,10-Dimethyl-1,2-benzanthracene 48-78 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 128-133 11160867-8 2001 Similarly, exposure of BU-11/BMS2 cocultures to 7,12-dimethylbenz[a]anthracene (DMBA), a prototypic PAH, down-regulated nuclear Rel A and c-Rel before overt apoptosis. 9,10-Dimethyl-1,2-benzanthracene 48-78 reticuloendotheliosis oncogene Mus musculus 138-143 11160867-8 2001 Similarly, exposure of BU-11/BMS2 cocultures to 7,12-dimethylbenz[a]anthracene (DMBA), a prototypic PAH, down-regulated nuclear Rel A and c-Rel before overt apoptosis. 9,10-Dimethyl-1,2-benzanthracene 80-84 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 128-133 11160867-8 2001 Similarly, exposure of BU-11/BMS2 cocultures to 7,12-dimethylbenz[a]anthracene (DMBA), a prototypic PAH, down-regulated nuclear Rel A and c-Rel before overt apoptosis. 9,10-Dimethyl-1,2-benzanthracene 80-84 reticuloendotheliosis oncogene Mus musculus 138-143 11160867-8 2001 Similarly, exposure of BU-11/BMS2 cocultures to 7,12-dimethylbenz[a]anthracene (DMBA), a prototypic PAH, down-regulated nuclear Rel A and c-Rel before overt apoptosis. Polycyclic Aromatic Hydrocarbons 100-103 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 128-133 11160867-8 2001 Similarly, exposure of BU-11/BMS2 cocultures to 7,12-dimethylbenz[a]anthracene (DMBA), a prototypic PAH, down-regulated nuclear Rel A and c-Rel before overt apoptosis. Polycyclic Aromatic Hydrocarbons 100-103 reticuloendotheliosis oncogene Mus musculus 138-143 11160867-9 2001 Finally, ectopic expression of Rel A or c-Rel rescued BU-11 cells from DMBA-induced apoptosis. bu-11 54-59 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 31-36 11160867-9 2001 Finally, ectopic expression of Rel A or c-Rel rescued BU-11 cells from DMBA-induced apoptosis. bu-11 54-59 reticuloendotheliosis oncogene Mus musculus 40-45 11160867-9 2001 Finally, ectopic expression of Rel A or c-Rel rescued BU-11 cells from DMBA-induced apoptosis. 9,10-Dimethyl-1,2-benzanthracene 71-75 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 31-36 11160867-9 2001 Finally, ectopic expression of Rel A or c-Rel rescued BU-11 cells from DMBA-induced apoptosis. 9,10-Dimethyl-1,2-benzanthracene 71-75 reticuloendotheliosis oncogene Mus musculus 40-45 11160867-10 2001 These results extend previous observations by demonstrating that 1) NF-kappaB is a survival factor at an earlier stage of B cell development than previously appreciated and 2) NF-kappaB down-regulation is likely to be part of the molecular mechanism resulting in PAH-induced preB cell apoptosis. Polycyclic Aromatic Hydrocarbons 263-266 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 68-77 11160867-10 2001 These results extend previous observations by demonstrating that 1) NF-kappaB is a survival factor at an earlier stage of B cell development than previously appreciated and 2) NF-kappaB down-regulation is likely to be part of the molecular mechanism resulting in PAH-induced preB cell apoptosis. Polycyclic Aromatic Hydrocarbons 263-266 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 176-185