PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11159438-6 2001 Mutation of two amino acids that are unique in the pore-loop complex of GIRK1 (F137S and A143T) restores K+ selectivity and eliminates the inhibition by extracellular local anesthetics, suggesting that the pore-loop complex prevents QX-314 from reaching the intrapore site. QX-314 233-239 potassium inwardly rectifying channel subfamily J member 3 Homo sapiens 72-77