PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11154562-2 2000 Under these conditions rate-determining Co-C heterolytic cleavage is preceded by rapid addition of cyanide to AdoCbl to form an intermediate, (beta-5"-deoxyadenosyl)(alpha-cyano)cobalamin ((beta-Ado)(alpha-CN)Cbl-), identified by 1H NMR spectroscopy. Cyanides 99-106 Cbl proto-oncogene Homo sapiens 113-116 11154562-7 2000 A mechanism in 92% DMF/8% D2O is proposed which involves rapid reversible formation of (beta-Ado)(alpha-CN)Cbl- from base-off AdoCbl plus cyanide, followed by rate-determining solvent-assisted cleavage of the Co-C bond of the intermediate and subsequent rapid addition of a second cyanide to give the products. Cyanides 138-145 Cbl proto-oncogene Homo sapiens 107-110 11154562-7 2000 A mechanism in 92% DMF/8% D2O is proposed which involves rapid reversible formation of (beta-Ado)(alpha-CN)Cbl- from base-off AdoCbl plus cyanide, followed by rate-determining solvent-assisted cleavage of the Co-C bond of the intermediate and subsequent rapid addition of a second cyanide to give the products. Cyanides 281-288 Cbl proto-oncogene Homo sapiens 107-110