PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11129289-4 2000 Paclitaxel was chosen for combination therapy in the preclinical study reported here due to its extensive use as a first-line therapy in ovarian cancer, its synergy with SCH58500 in preclinical cancer models, and its activation of p53-independent apoptosis, which might result in a "lowered threshold" for tumor cell death. Paclitaxel 0-10 tumor protein p53 Homo sapiens 231-234