PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11078636-5 2000 The effects of ECGF, histamine, and LPS on the presence of tPA and on enhancing the levels of mRNA reached maximum activity at 4 h and declined to levels below that of controls by 8 h. However, phorbol-treated cells exhibited reduced levels of tPA mRNA at 4 h, but was significantly increased by 8 h. A large-scale increase in PAI-1 mRNA steady-state levels was also stimulated by the agonists used in these studies. Histamine 21-30 plasminogen activator, tissue type Homo sapiens 59-62