PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11076697-0	2000	Silica induces nuclear factor-kappa B activation through tyrosine phosphorylation of I kappa B-alpha in RAW264.7 macrophages.	Tyrosine	57-65	NFKB inhibitor alpha	Homo sapiens	85-100	
11076697-2	2000	The question is raised whether PTK stimulation and NF-kappa B activation in silica-stimulated macrophages are directly connected through tyrosine phosphorylation of I kappa B-alpha.	Tyrosine	137-145	NFKB inhibitor alpha	Homo sapiens	165-180	
11076697-4	2000	Specific inhibitors of protein tyrosine kinase, such as genistein and tyrophostin AG126, prevented tyrosine phosphorylation of I kappa B-alpha in response to silica.	Tyrosine	31-39	NFKB inhibitor alpha	Homo sapiens	127-142	
11076697-7	2000	Antioxidants, such as superoxide dismutase (SOD), N-acetylcysteine (NAC), and pyrrolidine dithiocarbamate (PDTC), blocked tyrosine phosphorylation of I kappa B-alpha induced by silica, suggesting reactive oxygen species (ROS) may be important regulatory molecules in NF-kappa B activation through tyrosine phosphorylation of I kappa B-alpha.	Tyrosine	122-130	NFKB inhibitor alpha	Homo sapiens	150-165	
11076697-7	2000	Antioxidants, such as superoxide dismutase (SOD), N-acetylcysteine (NAC), and pyrrolidine dithiocarbamate (PDTC), blocked tyrosine phosphorylation of I kappa B-alpha induced by silica, suggesting reactive oxygen species (ROS) may be important regulatory molecules in NF-kappa B activation through tyrosine phosphorylation of I kappa B-alpha.	Tyrosine	122-130	NFKB inhibitor alpha	Homo sapiens	325-340	
11076697-7	2000	Antioxidants, such as superoxide dismutase (SOD), N-acetylcysteine (NAC), and pyrrolidine dithiocarbamate (PDTC), blocked tyrosine phosphorylation of I kappa B-alpha induced by silica, suggesting reactive oxygen species (ROS) may be important regulatory molecules in NF-kappa B activation through tyrosine phosphorylation of I kappa B-alpha.	Tyrosine	297-305	NFKB inhibitor alpha	Homo sapiens	150-165	
11076697-8	2000	The results suggest that tyrosine phosphorylation of I kappa B-alpha represents a proteasome proteolytic activity-independent mechanism for NF-kappa B activation that directly couples NF-kappa B to cellular tyrosine kinase in silica-stimulated macrophages.	Tyrosine	25-33	NFKB inhibitor alpha	Homo sapiens	53-68