PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11032244-1 2000 Insulin induces phosphorylation and activation of JAK2 tyrosine, as well as its association with STAT1 and SHP2 in insulin-sensitive tissues of intact rats, thus demonstrating a new pathway in transduction of insulin signals. Tyrosine 55-63 Janus kinase 2 Rattus norvegicus 50-54 11032244-5 2000 In the dexamethasone-treated group, the JAK2 protein concentrations increased but the stoichiometry of its phosphorylation decreased to 20%, whereas the JAK2/STAT1 and JAK2/SHP2 associations changed by 70% and 170%, respectively. Dexamethasone 7-20 Janus kinase 2 Rattus norvegicus 40-44 11032244-5 2000 In the dexamethasone-treated group, the JAK2 protein concentrations increased but the stoichiometry of its phosphorylation decreased to 20%, whereas the JAK2/STAT1 and JAK2/SHP2 associations changed by 70% and 170%, respectively. Dexamethasone 7-20 Janus kinase 2 Rattus norvegicus 153-157 11032244-5 2000 In the dexamethasone-treated group, the JAK2 protein concentrations increased but the stoichiometry of its phosphorylation decreased to 20%, whereas the JAK2/STAT1 and JAK2/SHP2 associations changed by 70% and 170%, respectively. Dexamethasone 7-20 signal transducer and activator of transcription 1 Rattus norvegicus 158-163 11032244-5 2000 In the dexamethasone-treated group, the JAK2 protein concentrations increased but the stoichiometry of its phosphorylation decreased to 20%, whereas the JAK2/STAT1 and JAK2/SHP2 associations changed by 70% and 170%, respectively. Dexamethasone 7-20 Janus kinase 2 Rattus norvegicus 153-157 11032244-5 2000 In the dexamethasone-treated group, the JAK2 protein concentrations increased but the stoichiometry of its phosphorylation decreased to 20%, whereas the JAK2/STAT1 and JAK2/SHP2 associations changed by 70% and 170%, respectively. Dexamethasone 7-20 protein tyrosine phosphatase, non-receptor type 11 Rattus norvegicus 173-177 11032244-6 2000 In fasting and dexamethasone-treated rats, therefore, insulin-induced JAK2 tyrosine phosphorylation decreases, and the JAK2 protein expression is differentially regulated such that the insulin-induced JAK2 association with SHP2 and STAT1 shows opposite interactions with the kinase. Dexamethasone 15-28 Janus kinase 2 Rattus norvegicus 70-74 11032244-6 2000 In fasting and dexamethasone-treated rats, therefore, insulin-induced JAK2 tyrosine phosphorylation decreases, and the JAK2 protein expression is differentially regulated such that the insulin-induced JAK2 association with SHP2 and STAT1 shows opposite interactions with the kinase. Dexamethasone 15-28 Janus kinase 2 Rattus norvegicus 119-123 11032244-6 2000 In fasting and dexamethasone-treated rats, therefore, insulin-induced JAK2 tyrosine phosphorylation decreases, and the JAK2 protein expression is differentially regulated such that the insulin-induced JAK2 association with SHP2 and STAT1 shows opposite interactions with the kinase. Dexamethasone 15-28 Janus kinase 2 Rattus norvegicus 119-123 11032244-6 2000 In fasting and dexamethasone-treated rats, therefore, insulin-induced JAK2 tyrosine phosphorylation decreases, and the JAK2 protein expression is differentially regulated such that the insulin-induced JAK2 association with SHP2 and STAT1 shows opposite interactions with the kinase. Dexamethasone 15-28 protein tyrosine phosphatase, non-receptor type 11 Rattus norvegicus 223-227 11032244-6 2000 In fasting and dexamethasone-treated rats, therefore, insulin-induced JAK2 tyrosine phosphorylation decreases, and the JAK2 protein expression is differentially regulated such that the insulin-induced JAK2 association with SHP2 and STAT1 shows opposite interactions with the kinase. Dexamethasone 15-28 signal transducer and activator of transcription 1 Rattus norvegicus 232-237 11032244-6 2000 In fasting and dexamethasone-treated rats, therefore, insulin-induced JAK2 tyrosine phosphorylation decreases, and the JAK2 protein expression is differentially regulated such that the insulin-induced JAK2 association with SHP2 and STAT1 shows opposite interactions with the kinase. Tyrosine 75-83 Janus kinase 2 Rattus norvegicus 70-74