PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10999799-3 2000 We aimed to define the maximal and the minimal stimulatory ACTH dose on cortisol, aldosterone, and dehydroepiandrosterone (DHEA) in humans. Dehydroepiandrosterone 99-121 proopiomelanocortin Homo sapiens 59-63 10999799-3 2000 We aimed to define the maximal and the minimal stimulatory ACTH dose on cortisol, aldosterone, and dehydroepiandrosterone (DHEA) in humans. Dehydroepiandrosterone 123-127 proopiomelanocortin Homo sapiens 59-63 10999799-12 2000 The DHEA deltaAUCs to all ACTH doses were significantly higher (P < 0.01) than that after placebo, showing a clear dose-response relationship (P < 0.001). Dehydroepiandrosterone 4-8 proopiomelanocortin Homo sapiens 26-30 10999799-14 2000 The DHEA response to 250.0 microg ACTH was not modified by pretreatment with 0.01, 0.03, 0.06, and 0.125 microg ACTH doses, whereas it was progressively reduced by pretreatment with 0.5, 1.0, and 25.0 microg ACTH doses (P < 0.01). Dehydroepiandrosterone 4-8 proopiomelanocortin Homo sapiens 34-38 10999799-15 2000 In conclusion, these results show that an extremely low ACTH dose is needed to stimulate adrenal steroids and, among them, DHEA seems the most sensitive to corticotropin stimulation. Dehydroepiandrosterone 123-127 proopiomelanocortin Homo sapiens 56-60