PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10995764-6 2000 Activation of phosphatidylinositol-3 kinase (PI3K) and its downstream effector Akt was also reduced in the Y1062F mutant but not completely abolished unless Tyr-1096 was also mutated. Tyrosine 157-160 AKT serine/threonine kinase 1 Homo sapiens 79-82 10995764-9 2000 These results indicate that upon ligand stimulation, at least two distinct protein complexes assemble on phosphorylated Tyr-1062 of c-Ret via Shc, one leading to activation of the Ras/Erk pathway through recruitment of Grb2/Sos and another to the PI3K/Akt pathway through recruitment of Grb2/Gab2 followed by p85(PI3K) and SHP-2. Tyrosine 120-123 AKT serine/threonine kinase 1 Homo sapiens 252-255