PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10804019-3	2000	We therefore investigated the role of hydrochlorothiazide (HCTZ) on OC production by the human osteoblast-like cell line MG-63.	Hydrochlorothiazide	38-57	bone gamma-carboxyglutamate protein	Homo sapiens	68-70	
10804019-3	2000	We therefore investigated the role of hydrochlorothiazide (HCTZ) on OC production by the human osteoblast-like cell line MG-63.	Hydrochlorothiazide	59-63	bone gamma-carboxyglutamate protein	Homo sapiens	68-70	
10804019-4	2000	HCTZ dose-dependently (1-100 microM) inhibited 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]-induced OC release by these cells (maximal effect, -40-50% and p < 0.005 by analysis of variance [ANOVA]) as measured by ELISA.	Hydrochlorothiazide	0-4	bone gamma-carboxyglutamate protein	Homo sapiens	94-96	
10804019-5	2000	This effect of HCTZ on OC release was caused by a direct effect on OC gene expression because Northern blot analysis revealed that OC messenger RNA (mRNA) levels were reduced in the presence of increasing doses of the diuretic (-47.2+/-4.0%; p < 0.0001 by paired ANOVA with 100 microM 13.6+/-0.49 pmol/mg protein/15 minutes; p < 0.05) in MG-63 cells.	Hydrochlorothiazide	15-19	bone gamma-carboxyglutamate protein	Homo sapiens	23-25	
10804019-5	2000	This effect of HCTZ on OC release was caused by a direct effect on OC gene expression because Northern blot analysis revealed that OC messenger RNA (mRNA) levels were reduced in the presence of increasing doses of the diuretic (-47.2+/-4.0%; p < 0.0001 by paired ANOVA with 100 microM 13.6+/-0.49 pmol/mg protein/15 minutes; p < 0.05) in MG-63 cells.	Hydrochlorothiazide	15-19	bone gamma-carboxyglutamate protein	Homo sapiens	67-69	
10804019-5	2000	This effect of HCTZ on OC release was caused by a direct effect on OC gene expression because Northern blot analysis revealed that OC messenger RNA (mRNA) levels were reduced in the presence of increasing doses of the diuretic (-47.2+/-4.0%; p < 0.0001 by paired ANOVA with 100 microM 13.6+/-0.49 pmol/mg protein/15 minutes; p < 0.05) in MG-63 cells.	Hydrochlorothiazide	15-19	bone gamma-carboxyglutamate protein	Homo sapiens	67-69	
10804019-13	2000	These studies indicate that HCTZ inhibits OC mRNA expression independently of an effect on VDR, YY1, or extracellular Ca2+ levels but involves changes in cFOS levels.	Hydrochlorothiazide	28-32	bone gamma-carboxyglutamate protein	Homo sapiens	42-44	
10804019-14	2000	As OC retards bone formation/mineralization, the inhibition of OC production by HCTZ could explain its preventive role in bone loss rate.	Hydrochlorothiazide	80-84	bone gamma-carboxyglutamate protein	Homo sapiens	3-5