PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10726708-2 2000 Inhibition by xenobiotics such as liquorice or mutations in the HSD11 B2 gene, as occur in the rare monogenic hypertensive syndrome of apparent mineralocorticoid excess (AME), result in a compromised 11 betaHSD2 enzyme activity, which in turn leads to overstimulation of the MR by cortisol, sodium retention, hypokalaemia, low plasma renin and aldosterone concentrations, and hypertension. Hydrocortisone 281-289 renin Homo sapiens 334-339