PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10715269-1 2000 BACKGROUND: The effects of type 1 angiotensin II receptor antagonist losartan and its metabolite E3174 on transmembrane action potentials, hKv1.5, HERG, and I(Ks) currents were analyzed. Losartan 69-77 type-1 angiotensin II receptor Cavia porcellus 27-57 10715269-4 2000 Losartan and E3174 transiently increased the hKv1.5 current by 8.0+/-1.4% and 7.4+/-1.6%, respectively. Losartan 0-8 potassium voltage-gated channel subfamily A member 5 Homo sapiens 45-51 10715269-4 2000 Losartan and E3174 transiently increased the hKv1.5 current by 8.0+/-1.4% and 7.4+/-1.6%, respectively. losartan carboxylic acid 13-18 potassium voltage-gated channel subfamily A member 5 Homo sapiens 45-51 10715269-12 2000 CONCLUSIONS: These results demonstrated that at therapeutic concentrations, both losartan and E3174 modified the cardiac delayed rectifier hKv1.5, HERG, and Ks currents. Losartan 81-89 potassium voltage-gated channel subfamily A member 5 Homo sapiens 139-145 10715269-12 2000 CONCLUSIONS: These results demonstrated that at therapeutic concentrations, both losartan and E3174 modified the cardiac delayed rectifier hKv1.5, HERG, and Ks currents. losartan carboxylic acid 94-99 potassium voltage-gated channel subfamily A member 5 Homo sapiens 139-145