PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10500210-2	1999	Prior studies have suggested a relationship between cholesterol metabolism and TGFbeta signaling.	Cholesterol	52-63	transforming growth factor beta 1	Homo sapiens	79-86	
10500210-3	1999	Here we demonstrate that induction of the cholesterol metabolic pathway by growth of embryonic chicken atrial cells in medium supplemented with lipoprotein-depleted serum coordinately decreased the expression of the TGFbeta type II receptor (TGFbetaRII), TGFbeta(1), and TGFbeta signaling as measured by plasminogen activator inhibitor-1 (PAI-1) promoter activity.	Cholesterol	42-53	transforming growth factor beta 1	Homo sapiens	216-223	
10500210-3	1999	Here we demonstrate that induction of the cholesterol metabolic pathway by growth of embryonic chicken atrial cells in medium supplemented with lipoprotein-depleted serum coordinately decreased the expression of the TGFbeta type II receptor (TGFbetaRII), TGFbeta(1), and TGFbeta signaling as measured by plasminogen activator inhibitor-1 (PAI-1) promoter activity.	Cholesterol	42-53	transforming growth factor beta 1	Gallus gallus	255-264	
10500210-3	1999	Here we demonstrate that induction of the cholesterol metabolic pathway by growth of embryonic chicken atrial cells in medium supplemented with lipoprotein-depleted serum coordinately decreased the expression of the TGFbeta type II receptor (TGFbetaRII), TGFbeta(1), and TGFbeta signaling as measured by plasminogen activator inhibitor-1 (PAI-1) promoter activity.	Cholesterol	42-53	transforming growth factor beta 1	Homo sapiens	242-249	
10500210-3	1999	Here we demonstrate that induction of the cholesterol metabolic pathway by growth of embryonic chicken atrial cells in medium supplemented with lipoprotein-depleted serum coordinately decreased the expression of the TGFbeta type II receptor (TGFbetaRII), TGFbeta(1), and TGFbeta signaling as measured by plasminogen activator inhibitor-1 (PAI-1) promoter activity.	Cholesterol	42-53	serpin family E member 1	Homo sapiens	339-344	
10500210-4	1999	Inhibition of the cholesterol metabolic pathway by the hydrophobic 3-hydroxy-3-methylglutaryl CoA (HMGCoA) reductase inhibitors, simvastatin and atorvastatin, reversed the effect of lipoprotein-depleted serum and up-regulated TGFbetaRII expression, whereas the hydrophilic HMGCoA reductase inhibitor, pravastatin, had no effect.	Cholesterol	18-29	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	273-289	
10500210-4	1999	Inhibition of the cholesterol metabolic pathway by the hydrophobic 3-hydroxy-3-methylglutaryl CoA (HMGCoA) reductase inhibitors, simvastatin and atorvastatin, reversed the effect of lipoprotein-depleted serum and up-regulated TGFbetaRII expression, whereas the hydrophilic HMGCoA reductase inhibitor, pravastatin, had no effect.	Simvastatin	129-140	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	273-289	
10500210-4	1999	Inhibition of the cholesterol metabolic pathway by the hydrophobic 3-hydroxy-3-methylglutaryl CoA (HMGCoA) reductase inhibitors, simvastatin and atorvastatin, reversed the effect of lipoprotein-depleted serum and up-regulated TGFbetaRII expression, whereas the hydrophilic HMGCoA reductase inhibitor, pravastatin, had no effect.	Atorvastatin	145-157	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	273-289	
10500210-5	1999	Simvastatin stimulated the expression of TGFbetaRII, TGFbeta(1), and PAI-1 at the level of transcription.	Simvastatin	0-11	transforming growth factor beta 1	Homo sapiens	41-48	
10500210-5	1999	Simvastatin stimulated the expression of TGFbetaRII, TGFbeta(1), and PAI-1 at the level of transcription.	Simvastatin	0-11	serpin family E member 1	Homo sapiens	69-74	
10500210-6	1999	Experiments using specific inhibitors of different branches of the cholesterol metabolic pathway demonstrated that simvastatin exerted its effect on TGFbeta signaling by inhibition of the geranylgeranylation pathway.	Cholesterol	67-78	transforming growth factor beta 1	Homo sapiens	149-156	
10500210-6	1999	Experiments using specific inhibitors of different branches of the cholesterol metabolic pathway demonstrated that simvastatin exerted its effect on TGFbeta signaling by inhibition of the geranylgeranylation pathway.	Simvastatin	115-126	transforming growth factor beta 1	Homo sapiens	149-156	
10500210-7	1999	C3 exotoxin, which specifically inactivates geranylgeranylated Rho GTPases, mimicked the effect of simvastatin on PAI-1 promoter activity.	Simvastatin	99-110	serpin family E member 1	Homo sapiens	114-119	
10500210-9	1999	These data support the conclusion that TGFbeta signaling is regulated by RhoA GTPase and demonstrate a relationship between cholesterol metabolism and TGFbeta signaling.	Cholesterol	124-135	transforming growth factor beta 1	Homo sapiens	39-46	
10500210-9	1999	These data support the conclusion that TGFbeta signaling is regulated by RhoA GTPase and demonstrate a relationship between cholesterol metabolism and TGFbeta signaling.	Cholesterol	124-135	transforming growth factor beta 1	Homo sapiens	151-158