PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10490706-7 1999 It should be noted that the association between the high-enzyme activity COMT val allele that increases CNS dopamine (and norepinephrine) clearance is consistent with the use of methylphenidate, an agent that increases dopamine (and norepinephrine) turnover, in the treatment of this disorder. Norepinephrine 122-136 catechol-O-methyltransferase Homo sapiens 73-77 10490706-7 1999 It should be noted that the association between the high-enzyme activity COMT val allele that increases CNS dopamine (and norepinephrine) clearance is consistent with the use of methylphenidate, an agent that increases dopamine (and norepinephrine) turnover, in the treatment of this disorder. Norepinephrine 233-247 catechol-O-methyltransferase Homo sapiens 73-77