PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10455185-6 1999 Irreversible inhibition of pro-ISG15 processing activity by thiol-specific alkylating agents and a pH rate dependence conforming to titration of a single group of pK(a) 8.1 indicate the 100-kDa enzyme is a thiol protease. Sulfhydryl Compounds 60-65 ISG15 ubiquitin like modifier Homo sapiens 31-36