PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10435011-7 1999 CONCLUSIONS: We conclude that in the conscious rat; (1) the pressor response to nicotine mainly depends on peripheral alpha-adrenergically-mediated vasoconstriction; (2) the vasomotor effect is caused by neural rather than adrenomedullary catecholamine release; (3) the nicotine-induced increase in heart rate (and presumably cardiac output) is per se unable to raise blood pressure, and (4) the nicotine-induced release of vasopressin plays no significant role in the pressor response. Nicotine 80-88 arginine vasopressin Rattus norvegicus 424-435