PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10427100-1	1999	Cryo-electron microscopy and three-dimensional, single-particle image analysis have been used to reveal the specific binding site of imperatoxin A (IpTx(a)) on the architecture of the calcium release channel/ryanodine receptor from skeletal muscle (RyR1).	iptx	148-152	ryanodine receptor 1	Homo sapiens	208-253	
10427100-2	1999	IpTx(a) is a peptide toxin that binds with high affinity to RyR1 and affects its functioning.	iptx	0-4	ryanodine receptor 1	Homo sapiens	60-64	
10427100-4	1999	IpTx(a) binds to the cytoplasmic moiety of RyR1 between the clamp and handle domains, 11 nm away from the transmembrane pore.	iptx	0-4	ryanodine receptor 1	Homo sapiens	43-47	
10427100-5	1999	The proposed mimicry by IpTx(a) of the dihydropyridine receptor (DHPR) II-III loop, thought to be a main physiological excitation-contraction trigger, suggests that the IpTx(a) binding location is a potential excitation-contraction signal transduction site.	iptx	24-28	calcium voltage-gated channel subunit alpha1 S	Homo sapiens	39-63	
10427100-5	1999	The proposed mimicry by IpTx(a) of the dihydropyridine receptor (DHPR) II-III loop, thought to be a main physiological excitation-contraction trigger, suggests that the IpTx(a) binding location is a potential excitation-contraction signal transduction site.	iptx	24-28	calcium voltage-gated channel subunit alpha1 S	Homo sapiens	65-69	
10427100-5	1999	The proposed mimicry by IpTx(a) of the dihydropyridine receptor (DHPR) II-III loop, thought to be a main physiological excitation-contraction trigger, suggests that the IpTx(a) binding location is a potential excitation-contraction signal transduction site.	iptx	169-173	calcium voltage-gated channel subunit alpha1 S	Homo sapiens	39-63	
10427100-5	1999	The proposed mimicry by IpTx(a) of the dihydropyridine receptor (DHPR) II-III loop, thought to be a main physiological excitation-contraction trigger, suggests that the IpTx(a) binding location is a potential excitation-contraction signal transduction site.	iptx	169-173	calcium voltage-gated channel subunit alpha1 S	Homo sapiens	65-69