PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10331647-1	1999	Glucose induces an increase in the intracellular Ca2+ concentration in pancreatic beta-cells to secrete insulin.	Glucose	0-7	insulin	Homo sapiens	104-111	
10331647-2	1999	CD38 occurs in beta-cells and has both ADP-ribosyl cyclase, which catalyzes the formation of cyclic ADP-ribose (cADPR) from NAD+, and cADPR hydrolase, which converts cADPR to ADP-ribose.	Cyclic ADP-Ribose	93-110	CD38 molecule	Homo sapiens	0-4	
10331647-2	1999	CD38 occurs in beta-cells and has both ADP-ribosyl cyclase, which catalyzes the formation of cyclic ADP-ribose (cADPR) from NAD+, and cADPR hydrolase, which converts cADPR to ADP-ribose.	NAD	124-128	CD38 molecule	Homo sapiens	0-4	
10331647-2	1999	CD38 occurs in beta-cells and has both ADP-ribosyl cyclase, which catalyzes the formation of cyclic ADP-ribose (cADPR) from NAD+, and cADPR hydrolase, which converts cADPR to ADP-ribose.	Adenosine Diphosphate Ribose	100-110	CD38 molecule	Homo sapiens	0-4	
10331647-3	1999	ATP, produced by glucose metabolism, competes with cADPR for the binding site, Lys-129, of CD38, resulting in the inhibition of the hydrolysis of cADPR and thereby causing cADPR accumulation in beta-cells.	Adenosine Triphosphate	0-3	CD38 molecule	Homo sapiens	91-95	
10331647-3	1999	ATP, produced by glucose metabolism, competes with cADPR for the binding site, Lys-129, of CD38, resulting in the inhibition of the hydrolysis of cADPR and thereby causing cADPR accumulation in beta-cells.	Glucose	17-24	CD38 molecule	Homo sapiens	91-95	
10331647-3	1999	ATP, produced by glucose metabolism, competes with cADPR for the binding site, Lys-129, of CD38, resulting in the inhibition of the hydrolysis of cADPR and thereby causing cADPR accumulation in beta-cells.	Lysine	79-82	CD38 molecule	Homo sapiens	91-95	
10331647-4	1999	Cyclic ADP-ribose then binds to FK506-binding protein 12.6 in the ryanodine receptor Ca2+ channel (RyR), dissociating the binding protein from RyR to induce the release of Ca2+ from the endoplasmic reticulum.	Cyclic ADP-Ribose	0-17	FKBP prolyl isomerase 1B	Homo sapiens	32-58	
10331647-4	1999	Cyclic ADP-ribose then binds to FK506-binding protein 12.6 in the ryanodine receptor Ca2+ channel (RyR), dissociating the binding protein from RyR to induce the release of Ca2+ from the endoplasmic reticulum.	Cyclic ADP-Ribose	0-17	ryanodine receptor 2	Homo sapiens	99-102	
10331647-4	1999	Cyclic ADP-ribose then binds to FK506-binding protein 12.6 in the ryanodine receptor Ca2+ channel (RyR), dissociating the binding protein from RyR to induce the release of Ca2+ from the endoplasmic reticulum.	Cyclic ADP-Ribose	0-17	ryanodine receptor 2	Homo sapiens	143-146