PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10228013-1	1999	Several reports have shown that bicyclic imidazoles, specific inhibitors of the p38 mitogen-activated protein kinase (MAPK), block cytokine synthesis at the translational level.	bicyclic imidazoles	32-51	mitogen-activated protein kinase 14	Mus musculus	80-83	
10228013-2	1999	In this study, we examined the role of p38 MAPK in the regulation of the IL-1beta cytokine gene in monocytic cell lines using the bicyclic imidazole SB203580.	imidazole	139-148	interleukin 1 beta	Mus musculus	73-81	
10228013-2	1999	In this study, we examined the role of p38 MAPK in the regulation of the IL-1beta cytokine gene in monocytic cell lines using the bicyclic imidazole SB203580.	SB 203580	149-157	interleukin 1 beta	Mus musculus	73-81	
10228013-3	1999	Addition of SB203580 30 min before stimulation of monocytes with LPS inhibited IL-1beta protein and steady state message in a dose-dependent manner in both RAW264.7 and J774 cell lines.	SB 203580	12-20	toll-like receptor 4	Mus musculus	65-68	
10228013-3	1999	Addition of SB203580 30 min before stimulation of monocytes with LPS inhibited IL-1beta protein and steady state message in a dose-dependent manner in both RAW264.7 and J774 cell lines.	SB 203580	12-20	interleukin 1 beta	Mus musculus	79-87	
10228013-6	1999	LPS-stimulated p38 MAPK activity in the RAW264.7 cells was blocked by SB203580, as measured by the inhibition of MAPKAP2 kinase activity, a downstream target of the p38 MAPK.	SB 203580	70-78	toll-like receptor 4	Mus musculus	0-3	
10228013-6	1999	LPS-stimulated p38 MAPK activity in the RAW264.7 cells was blocked by SB203580, as measured by the inhibition of MAPKAP2 kinase activity, a downstream target of the p38 MAPK.	SB 203580	70-78	mitogen-activated protein kinase 14	Mus musculus	15-18	
10228013-6	1999	LPS-stimulated p38 MAPK activity in the RAW264.7 cells was blocked by SB203580, as measured by the inhibition of MAPKAP2 kinase activity, a downstream target of the p38 MAPK.	SB 203580	70-78	mitogen-activated protein kinase 14	Mus musculus	15-23	
10228013-7	1999	CCAATT/enhancer binding protein (C/EBP)/NFIL-6-driven chloramphenicol acetyltransferase (CAT) reporter activity was sensitive to SB203580, indicating that C/EBP/NFIL-6 transcription factor(s) are also targets of p38 MAPK.	SB 203580	129-137	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	0-31	
10228013-7	1999	CCAATT/enhancer binding protein (C/EBP)/NFIL-6-driven chloramphenicol acetyltransferase (CAT) reporter activity was sensitive to SB203580, indicating that C/EBP/NFIL-6 transcription factor(s) are also targets of p38 MAPK.	SB 203580	129-137	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	33-38	
10228013-7	1999	CCAATT/enhancer binding protein (C/EBP)/NFIL-6-driven chloramphenicol acetyltransferase (CAT) reporter activity was sensitive to SB203580, indicating that C/EBP/NFIL-6 transcription factor(s) are also targets of p38 MAPK.	SB 203580	129-137	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	40-46	
10228013-7	1999	CCAATT/enhancer binding protein (C/EBP)/NFIL-6-driven chloramphenicol acetyltransferase (CAT) reporter activity was sensitive to SB203580, indicating that C/EBP/NFIL-6 transcription factor(s) are also targets of p38 MAPK.	SB 203580	129-137	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	155-160	
10228013-7	1999	CCAATT/enhancer binding protein (C/EBP)/NFIL-6-driven chloramphenicol acetyltransferase (CAT) reporter activity was sensitive to SB203580, indicating that C/EBP/NFIL-6 transcription factor(s) are also targets of p38 MAPK.	SB 203580	129-137	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	161-167	
10228013-7	1999	CCAATT/enhancer binding protein (C/EBP)/NFIL-6-driven chloramphenicol acetyltransferase (CAT) reporter activity was sensitive to SB203580, indicating that C/EBP/NFIL-6 transcription factor(s) are also targets of p38 MAPK.	SB 203580	129-137	mitogen-activated protein kinase 14	Mus musculus	212-220	
10228013-8	1999	In contrast, transfected CAT constructs containing NF-kappaB elements were only partially inhibited (approximately 35%) at the highest concentration of SB203580 after LPS stimulation.	SB 203580	152-160	toll-like receptor 4	Mus musculus	167-170