PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
23238017-2	2012	We have identified distinct derivatives of medicinal active phenothiazines, namely mepazine, thioridazine, and promazine, as small molecule inhibitors of the MALT1 protease.	mepazine	83-91	MALT1 paracaspase	Homo sapiens	158-172
25043939-8	2014	Importantly, while complete absence of MALT1 affects the differentiation of regulatory T (Treg) cells in vivo, the MALT1 protease inhibitor mepazine did not affect Treg development.	mepazine	140-148	MALT1 paracaspase	Mus musculus	115-120
34753803-6	2022	Treatment of mice with mepazine, a pharmacologic MALT1 inhibitor, reduced growth of PAR1+, MDA-MB-231 xenografts and had an even more dramatic effect in reducing the burden of metastatic disease.	mepazine	23-31	MALT1 paracaspase	Mus musculus	49-54
34753803-6	2022	Treatment of mice with mepazine, a pharmacologic MALT1 inhibitor, reduced growth of PAR1+, MDA-MB-231 xenografts and had an even more dramatic effect in reducing the burden of metastatic disease.	mepazine	23-31	coagulation factor II (thrombin) receptor	Mus musculus	84-88
31291468-0	2020	Biperiden and mepazine effectively inhibit MALT1 activity and tumor growth in pancreatic cancer.	mepazine	14-22	MALT1 paracaspase	Homo sapiens	43-48
31291468-5	2020	Mepazine (Mep), a phenothiazine derivative, is a known potent MALT1 inhibitor.	mepazine	0-8	MALT1 paracaspase	Homo sapiens	62-67
31291468-5	2020	Mepazine (Mep), a phenothiazine derivative, is a known potent MALT1 inhibitor.	mepazine	0-3	MALT1 paracaspase	Homo sapiens	62-67
30158289-8	2018	Disease development was also delayed in mice treated with the MALT1 protease inhibitor mepazine and in knock-in mice expressing a catalytically inactive MALT1 mutant protein, showing an important role of MALT1 proteolytic activity.	mepazine	87-95	MALT1 paracaspase	Mus musculus	62-67
30513612-0	2018	Mepazine Inhibits RANK-Induced Osteoclastogenesis Independent of Its MALT1 Inhibitory Function.	mepazine	0-8	MALT1 paracaspase	Mus musculus	69-74
30513612-5	2018	The treatment of mouse bone marrow precursor cells with mepazine strongly inhibited the RANK ligand (RANKL)-induced formation of osteoclasts, as well as the expression of several osteoclast markers, such as TRAP, cathepsin K, and calcitonin.	mepazine	56-64	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	88-99
30513612-5	2018	The treatment of mouse bone marrow precursor cells with mepazine strongly inhibited the RANK ligand (RANKL)-induced formation of osteoclasts, as well as the expression of several osteoclast markers, such as TRAP, cathepsin K, and calcitonin.	mepazine	56-64	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	101-106
30513612-5	2018	The treatment of mouse bone marrow precursor cells with mepazine strongly inhibited the RANK ligand (RANKL)-induced formation of osteoclasts, as well as the expression of several osteoclast markers, such as TRAP, cathepsin K, and calcitonin.	mepazine	56-64	cathepsin K	Mus musculus	213-224
29367251-12	2018	Finally, treatment of wild-type mice with mepazine, a MALT1 protease inhibitor, also led to mortality upon ERA virus infection.	mepazine	42-50	MALT1 paracaspase	Mus musculus	54-59
27105502-4	2016	In the present study, we examined the pharmacological effect of two specific MALT1 inhibitors MI-2 and mepazine on the dextran sulfate sodium (DSS)-induced experimental colitis in mice, followed by mechanistic analysis on NF-kappaB and NLRP3 inflammasome activation.	mepazine	103-111	MALT1 paracaspase	Mus musculus	77-82
27071417-8	2016	Inhibition of MALT1 with mepazine reduced CARD14(E138A)-induced expression of specific psoriasis-associated transcripts in keratinocytes.	mepazine	25-33	MALT1 paracaspase	Homo sapiens	14-19
27071417-8	2016	Inhibition of MALT1 with mepazine reduced CARD14(E138A)-induced expression of specific psoriasis-associated transcripts in keratinocytes.	mepazine	25-33	caspase recruitment domain family member 14	Homo sapiens	42-48
26540570-6	2015	Combined inhibition of BTK by Ibrutinib and MALT1 by S-Mepazine additively impaired MALT1 cleavage activity and expression of NF-kappaB pro-survival factors.	mepazine	53-63	Bruton tyrosine kinase	Homo sapiens	23-26
26540570-6	2015	Combined inhibition of BTK by Ibrutinib and MALT1 by S-Mepazine additively impaired MALT1 cleavage activity and expression of NF-kappaB pro-survival factors.	mepazine	53-63	MALT1 paracaspase	Homo sapiens	44-49
26540570-6	2015	Combined inhibition of BTK by Ibrutinib and MALT1 by S-Mepazine additively impaired MALT1 cleavage activity and expression of NF-kappaB pro-survival factors.	mepazine	53-63	MALT1 paracaspase	Homo sapiens	84-89
26540570-8	2015	Moreover, while expression of oncogenic CARMA1 in CD79 mutant cells conferred Ibrutinib resistance, double mutant cells were still sensitive to MALT1 inhibition by S-Mepazine.	mepazine	164-174	MALT1 paracaspase	Homo sapiens	144-149