PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
32273810-0	2020	Anticancer activity of THMPP: Downregulation of PI3K/ S6K1 in breast cancer cell line.	thmpp	23-28	ribosomal protein S6 kinase B1	Homo sapiens	54-58
32273810-6	2020	THMPP at IC50 concentration of 83.23 muM and 113.94 muM, induced cell death in MCF-7 and SkBr3 cells, respectively.	thmpp	0-5	latexin	Homo sapiens	37-40
32273810-6	2020	THMPP at IC50 concentration of 83.23 muM and 113.94 muM, induced cell death in MCF-7 and SkBr3 cells, respectively.	thmpp	0-5	latexin	Homo sapiens	52-55
32273810-7	2020	Increased level of caspase-3 and -9, fragmentation of DNA, translocation of phosphatidylserine membrane and morphological changes in the cells confirmed the effect of THMPP in inducing the apoptosis.	thmpp	167-172	caspase 3	Homo sapiens	19-35
32273810-8	2020	Gene expression analysis has shown that THMPP was able to downregulate the expression of PI3K/S6K1 genes, possibly via EGFR signaling pathway in both the cell lines, MCF-7 and SkBr3.	thmpp	40-45	ribosomal protein S6 kinase B1	Homo sapiens	94-98
32273810-8	2020	Gene expression analysis has shown that THMPP was able to downregulate the expression of PI3K/S6K1 genes, possibly via EGFR signaling pathway in both the cell lines, MCF-7 and SkBr3.	thmpp	40-45	epidermal growth factor receptor	Homo sapiens	119-123
32273810-9	2020	Further, molecular docking also confirms the potential binding of THMPP with EGFR.	thmpp	66-71	epidermal growth factor receptor	Homo sapiens	77-81
32273810-11	2020	Overall, the results suggest that THMPP induced cell death might be regulated by EGFR signaling pathway which augments THMPP being developed as a potential candidate for treating breast cancer.	thmpp	34-39	epidermal growth factor receptor	Homo sapiens	81-85
32273810-11	2020	Overall, the results suggest that THMPP induced cell death might be regulated by EGFR signaling pathway which augments THMPP being developed as a potential candidate for treating breast cancer.	thmpp	119-124	epidermal growth factor receptor	Homo sapiens	81-85