PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
29450744-8	2018	Moreover, the S1P3 inhibitor suramin prevented VEGFR2 expression and abolished endothelial migration and tube formation, while the S1P1 agonist CYM-5442 and the S1P2 inhibitor JTE-013 had no effect.	2-(4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino)ethanol	144-152	sphingosine-1-phosphate receptor 1	Homo sapiens	131-135
35326420-8	2022	Using laser photocoagulation rupture of Bruch"s membrane to induce choroidal neovascularization, we show that S1PR non-selective (FTY720) and S1PR1 selective (CYM5442) agonists significantly inhibit choroidal neovascularization in this model.	2-(4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino)ethanol	159-166	sphingosine-1-phosphate receptor 1	Homo sapiens	142-147
30918324-4	2019	Immune-mediated pulmonary injury is aggravated by the absence of endothelial S1PR1 and alleviated by treatment with CYM-5442, suggesting a protective function of S1PR1 signaling during H1N1 infection.	2-(4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino)ethanol	116-124	sphingosine-1-phosphate receptor 1	Mus musculus	162-167
30918324-7	2019	Combined administration of the S1PR1 agonist CYM-5442 and the antiviral drug oseltamivir provides maximum protection from ALI.	2-(4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino)ethanol	45-53	sphingosine-1-phosphate receptor 1	Mus musculus	31-36
29945931-3	2018	FTY720 produced antinociception and antiallodynia, respectively, and these effects were dose-dependent and mimicked by the S1PR1-selective agonist CYM-5442.	2-(4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino)ethanol	147-155	sphingosine-1-phosphate receptor 1	Mus musculus	123-128
31603252-7	2020	The S1P1 agonist, CYM-5442 (1 mg/kg), was injected intraperitoneally after surgery.	2-(4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino)ethanol	18-26	sphingosine-1-phosphate receptor 1	Rattus norvegicus	4-8
29193293-7	2018	CYM5442 treatment during the brief cuprizone exposure significantly prevented Il-1beta, Il-6, Cxcl10, and Cxcl3 induction, resulting in suppression of subsequent reactive gliosis and demyelination.	2-(4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino)ethanol	0-7	chemokine (C-X-C motif) ligand 3	Mus musculus	106-111
28325871-1	2017	Blockade of IFN-alpha but not IFN-beta signaling using either an antibody or a selective S1PR1 agonist, CYM-5442, prevented type 1 diabetes (T1D) in the mouse Rip-LCMV T1D model.	2-(4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino)ethanol	104-112	regulation of phenobarbitol-inducible P450	Mus musculus	159-162
29193293-7	2018	CYM5442 treatment during the brief cuprizone exposure significantly prevented Il-1beta, Il-6, Cxcl10, and Cxcl3 induction, resulting in suppression of subsequent reactive gliosis and demyelination.	2-(4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino)ethanol	0-7	interleukin 1 beta	Mus musculus	78-86
29193293-7	2018	CYM5442 treatment during the brief cuprizone exposure significantly prevented Il-1beta, Il-6, Cxcl10, and Cxcl3 induction, resulting in suppression of subsequent reactive gliosis and demyelination.	2-(4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino)ethanol	0-7	interleukin 6	Mus musculus	88-92
29193293-7	2018	CYM5442 treatment during the brief cuprizone exposure significantly prevented Il-1beta, Il-6, Cxcl10, and Cxcl3 induction, resulting in suppression of subsequent reactive gliosis and demyelination.	2-(4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino)ethanol	0-7	chemokine (C-X-C motif) ligand 10	Mus musculus	94-100
28399143-0	2017	Sphingosine 1-phosphate receptor 1 (S1PR1) agonist CYM5442 inhibits expression of intracellular adhesion molecule 1 (ICAM1) in endothelial cells infected with influenza A viruses.	2-(4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino)ethanol	51-58	sphingosine-1-phosphate receptor 1	Homo sapiens	36-41
28399143-0	2017	Sphingosine 1-phosphate receptor 1 (S1PR1) agonist CYM5442 inhibits expression of intracellular adhesion molecule 1 (ICAM1) in endothelial cells infected with influenza A viruses.	2-(4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino)ethanol	51-58	intercellular adhesion molecule 1	Homo sapiens	117-122
28399143-4	2017	In this report, we tested our hypothesis that S1PR1 agonist CYM5442 inhibits expression of intracellular adhesion molecules 1 (ICAM1) in endothelial cells infected with influenza A virus.	2-(4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino)ethanol	60-67	sphingosine-1-phosphate receptor 1	Homo sapiens	46-51
28399143-4	2017	In this report, we tested our hypothesis that S1PR1 agonist CYM5442 inhibits expression of intracellular adhesion molecules 1 (ICAM1) in endothelial cells infected with influenza A virus.	2-(4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino)ethanol	60-67	intercellular adhesion molecule 1	Homo sapiens	127-132
28399143-10	2017	Addition of CYM5442 in culture media reduced the production of ICAM1 via a dosage- and time-dependent manner.	2-(4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino)ethanol	12-19	intercellular adhesion molecule 1	Homo sapiens	63-68
28399143-11	2017	CYM5442 inhibited the activation of nuclear factor (NF)-kappaB.	2-(4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino)ethanol	0-7	nuclear factor kappa B subunit 1	Homo sapiens	36-62
28399143-12	2017	The regulatory effects of CYM5442 were beta-arrestin2-dependent.	2-(4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino)ethanol	26-33	arrestin beta 2	Homo sapiens	39-53
25088224-0	2015	The S1P1 receptor-selective agonist CYM-5442 reduces the severity of acute GVHD by inhibiting macrophage recruitment.	2-(4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino)ethanol	36-44	sphingosine-1-phosphate receptor 1	Homo sapiens	4-8
25088224-4	2015	In this study, we investigated the effect of an S1P1-selective agonist, CYM-5442, on the progression of aGVHD.	2-(4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino)ethanol	72-80	sphingosine-1-phosphate receptor 1	Homo sapiens	48-52
25880547-12	2015	However, after pretreatment with CYM-5442 (selective for S1PR1), SEW2871 was ineffective, but S1P increased the excitability of some, but not all, sensory neurons.	2-(4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino)ethanol	33-41	sphingosine-1-phosphate receptor 1	Rattus norvegicus	57-62
25010202-9	2014	Blockade of the egress of cells from the spleen was performed by administration of the Sphingosine-1-phosphate receptor 1 (S1P1) agonist CYM-5442 10 h after L/IM.	2-(4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino)ethanol	137-145	sphingosine-1-phosphate receptor 1	Mus musculus	87-121
25010202-9	2014	Blockade of the egress of cells from the spleen was performed by administration of the Sphingosine-1-phosphate receptor 1 (S1P1) agonist CYM-5442 10 h after L/IM.	2-(4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino)ethanol	137-145	sphingosine-1-phosphate receptor 1	Mus musculus	123-127
21435724-7	2011	To further characterize SphK1-dependent IL-12p70 regulation we exogenously applied S1P, SEW2871 and the new potent S1P1 agonist CYM5442.	2-(4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino)ethanol	128-135	sphingosine kinase 1	Mus musculus	24-29
21435724-7	2011	To further characterize SphK1-dependent IL-12p70 regulation we exogenously applied S1P, SEW2871 and the new potent S1P1 agonist CYM5442.	2-(4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino)ethanol	128-135	sphingosine-1-phosphate receptor 1	Mus musculus	115-119